All Stories

  1. Decreased BECN1 mRNA Expression in Human Breast Cancer is Associated With Estrogen Receptor-Negative Subtypes and Poor Prognosis

    Article • EBioMedicine, March 2015, Elsevier

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  2. NaGdF4 Nanoparticles Coated with Functionalised Ethylenediaminetetraacetic Acid as Versatile Probes for Dual Optical and Magnetic Resonance Imaging

    Article • ChemPlusChem, October 2014, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  3. PTEN regulates plasma membrane expression of glucose transporter 1 and glucose uptake in thyroid cancer cells

    Article • August 2014, Bioscientifica

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  4. Turmeric Toxicity in A431 Epidermoid Cancer Cells Associates with Autophagy Degradation of Anti‐apoptotic and Anti‐autophagic p53 Mutant

    Article • Phytotherapy Research, July 2014, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  5. Epigenetic Control of Autophagy by MicroRNAs in Ovarian Cancer

    Article • BioMed Research International, January 2014, Hindawi Publishing Corporation

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  6. Single Amino Acid Arginine Deprivation Triggers Prosurvival Autophagic Response in Ovarian Carcinoma SKOV3

    Article • BioMed Research International, January 2014, Hindawi Publishing Corporation

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  7. Expression and Clinical Significance of the Autophagy Proteins BECLIN 1 and LC3 in Ovarian Cancer

    Article • BioMed Research International, January 2014, Hindawi Publishing Corporation

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  8. Autophagy and thyroid carcinogenesis: genetic and epigenetic links

    Article • October 2013, Bioscientifica

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  9. Protection from UVB Toxicity in Human Keratinocytes by Thailand Native Herbs Extracts

    Article • Photochemistry and Photobiology, September 2013, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  10. Knockdown of cathepsin D in zebrafish fertilized eggs determines congenital myopathy

    Article • Bioscience Reports, April 2013, Portland Press Ltd.

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  11. Similarities and differences in the biogenesis, processing and lysosomal targeting between zebrafish and human pro-Cathepsin D: Functional implications

    Article • The International Journal of Biochemistry & Cell Biology, February 2013, Elsevier

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  12. Cathepsins: Getting in Shape for Lysosomal Proteolysis

    Article • January 2013, Springer Science + Business Media

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  13. Involvement of autophagy in ovarian cancer: a working hypothesis

    Article • Journal of Ovarian Research, September 2012, Springer Science + Business Media

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  14. Defective Autophagy in Parkinson’s Disease: Role of Oxidative Stress

    Article • Molecular Neurobiology, August 2012, Springer Science + Business Media

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  15. Dopamine induces apoptosis in APPswe-expressing Neuro2A cells following Pepstatin-sensitive proteolysis of APP in acid compartments

    Article • Brain Research, August 2012, Elsevier

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  16. Biocompatibility, endocytosis, and intracellular trafficking of mesoporous silica and polystyrene nanoparticles in ovarian cancer cells: effects of size and surface charge groups

    Article • International Journal of Nanomedicine, July 2012, Taylor & Francis

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  17. Labeling and exocytosis of secretory compartments in RBL mastocytes by polystyrene and mesoporous silica nanoparticles

    Article • International Journal of Nanomedicine, April 2012, Dove Medical Press

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  18. Induced autophagy reduces virus output in dengue infected monocytic cells

    Article • Virology, September 2011, Elsevier

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  19. Knock-Down of Cathepsin D Affects the Retinal Pigment Epithelium, Impairs Swim-Bladder Ontogenesis and Causes Premature Death in Zebrafish

    Article • PLoS ONE, July 2011, PLOS

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  20. Patented Biomarkers for the Early Detection of Ovarian Cancer

    Article • Recent Patents on Biomarkers, March 2011, Bentham Science Publishers

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  21. Resveratrol Reduces the Invasive Growth and Promotes the Acquisition of a Long-Lasting Differentiated Phenotype in Human Glioblastoma Cells

    Article • Journal of Agricultural and Food Chemistry, March 2011, American Chemical Society (ACS)

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  22. Autophagy-active beclin-1 correlates with favourable clinical outcome in non-Hodgkin lymphomas

    Article • Modern Pathology, July 2010, Elsevier

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  23. Differential role of cathepsins B and L in autophagy-associated cell death induced by arsenic trioxide in U87 human glioblastoma cells

    Article • Biological Chemistry, May 2010, De Gruyter

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  24. High Expression of Cathepsin D in Non-Hodgkin’s Lymphomas Negatively Impacts on Clinical Outcome

    Article • Disease Markers, January 2010, Hindawi Publishing Corporation

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  25. Autophagy, lithium, and amyotrophic lateral sclerosis

    Article • Muscle & Nerve, July 2009, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  26. Chemotherapy drug response in ovarian cancer cells strictly depends on a cathepsin D‐Bax activation loop

    Article • Journal of Cellular and Molecular Medicine, June 2009, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  27. Photoactive Hybrid Nanomaterials: Indocyanine Immobilized in Mesoporous MCM-41 for “In-Cell” Bioimaging

    Article • ACS Applied Materials & Interfaces, March 2009, American Chemical Society (ACS)

    Professor Ciro Isidoro, Dr Enrica Gianotti, Professor CIRO ISIDORO

  28. Role of Autophagy during Methamphetamine Neurotoxicity

    Article • Annals of the New York Academy of Sciences, October 2008, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  29. Prolactin Promotes the Secretion of Active Cathepsin D at the Basal Side of Rat Mammary Acini

    Article • Endocrinology, August 2008, Endocrine Society

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  30. Suppression of autophagy precipitates neuronal cell death following low doses of methamphetamine

    Article • Journal of Neurochemistry, July 2008, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  31. Autophagy and amyotrophic lateral sclerosis: The multiple roles of lithium

    Article • Autophagy, May 2008, Taylor & Francis

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  32. Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression

    Article • European Journal of Neuroscience, March 2008, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  33. A fast and simple method for simultaneous mixed site‐specific mutagenesis of a wide coding sequence

    Article • Biotechnology and Applied Biochemistry, February 2008, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  34. Folding, activity and targeting of mutated human cathepsin D that cannot be processed into the double-chain form

    Article • The International Journal of Biochemistry & Cell Biology, January 2007, Elsevier

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  35. PI3K-dependent lysosome exocytosis in nitric oxide-preconditioned hepatocytes

    Article • Free Radical Biology and Medicine, May 2006, Elsevier

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  36. cFLIP expression correlates with tumour progression and patient outcome in non‐Hodgkin lymphomas of low grade of malignancy

    Article • British Journal of Haematology, January 2006, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  37. High yield synthesis and characterization of phosphorylated recombinant human procathepsin D expressed in mammalian cells

    Article • Protein Expression and Purification, January 2006, Elsevier

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  38. Destination ‘Lysosome’: a target organelle for tumour cell killing?

    Article • Journal of Molecular Recognition, September 2003, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  39. Increase in Ceramide Level Alters the Lysosomal Targeting of Cathepsin D prior to Onset of Apoptosis in HT-29 Colon Cancer Cells

    Article • Biological Chemistry, January 2002, De Gruyter

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  40. Lysosomal proteases as potential targets for the induction of apoptotic cell death in human neuroblastomas

    Article • International Journal of Cancer, November 2001, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  41. Expression of protein kinase C ?1 confers resistance to TNF?- and paclitaxel-induced apoptosis in HT-29 colon carcinoma cells

    Article • International Journal of Cancer, January 2001, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  42. Transformation by oncogenic ras‐p21 alters the processing and subcellular localization of the lysosomal protease cathepsin D

    Article • Journal of Cellular Biochemistry, June 1999, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  43. Transformation by oncogenic ras-p21 alters the processing and subcellular localization of the lysosomal protease cathepsin D

    Article • Journal of Cellular Biochemistry, June 1999, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  44. Regulation of rat hepatocyte protein kinase C ? isoenzymes by the lipid peroxidation product 4-hydroxy-2,3-nonenal: A signaling pathway to modulate vesicular transport of glycoproteins

    Article • Hepatology, May 1999, Wolters Kluwer Health

    Professor Ciro Isidoro, Professor Fiorella Biasi, Professor CIRO ISIDORO

  45. Lysosomal segregation of a mannose-rich glycoprotein imparted by the prosequence of myeloperoxidase

    Article • Journal of Cellular Biochemistry, November 1998, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  46. Differentiation-induced changes in the content, secretion, and subcellular distribution of lysosomal cathepsins in the human colon cancer HT-29 cell line

    Article • Cell and Tissue Research, June 1997, Springer Science + Business Media

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  47. Mis-sorting of procathepsin D in metastogenic tumor cells is not due to impaired synthesis of the phosphomannosyl signal

    Article • International Journal of Cancer, March 1997, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  48. Differential targeting and processing of procathepsin D in normal and transformed murine 3T3 fibroblasts

    Article • International Journal of Cancer, January 1997, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  49. Synthesis, maturation and extracellular release of procathepsin D as influenced by cell proliferation or transformation

    Article • International Journal of Cancer, December 1995, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  50. Altered intracellular processing and enhanced secretion of procathepsin D in a highly deviated rat hepatoma

    Article • International Journal of Cancer, January 1995, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  51. Effects of Calcitriol on the Biogenesis of a Lysosomal Protease in Monocytes from Patients with Renal Failure

    Article • January 1994, Karger Publishers

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  52. Role of monocytes in cryoglobulinemia-associated nephritis

    Article • Kidney International, May 1993, Elsevier

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  53. Serum and Intracellular Detection of Cytokines in Patients Undergoing Chronic Hemodialysis

    Article • Artificial Organs, April 1992, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  54. Altered transport and processing of cathepsin D in human tumour cells with metastatic phenotype

    Article • European Journal of Cancer and Clinical Oncology, January 1991, Elsevier

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  55. Suppression of the ‘uncovering’ of mannose‐6‐phosphate residues in lysosomal enzymes in the presence of NH4Cl

    Article • European Journal of Biochemistry, August 1990, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  56. Brefeldin A Prevents Uncovering but not Phosphorylation of the Recognition Marker in Cathepsin D

    Article • Biological Chemistry Hoppe-Seyler, January 1990, De Gruyter

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  57. Regulation of Protein Degradation in Neoplastic Cells

    Article • January 1988, Springer Science + Business Media

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  58. The transport of soluble lysosomal hydrolases from the Golgi complex to lysosomes

    Article • Springer Science + Business Media

    Professor Ciro Isidoro, Professor CIRO ISIDORO