All Stories

  1. Decreased BECN1 mRNA Expression in Human Breast Cancer is Associated With Estrogen Receptor-Negative Subtypes and Poor Prognosis

    Article • EBioMedicine, March 2015, Elsevier

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  2. NaGdF4Nanoparticles Coated with Functionalised Ethylenediaminetetraacetic Acid as Versatile Probes for Dual Optical and Magnetic Resonance Imaging

    Article • ChemPlusChem, October 2014, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  3. PTEN regulates plasma membrane expression of glucose transporter 1 and glucose uptake in thyroid cancer cells

    Article • August 2014, Bioscientifica

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  4. Turmeric Toxicity in A431 Epidermoid Cancer Cells Associates with Autophagy Degradation of Anti-apoptotic and Anti-autophagic p53 Mutant

    Article • Phytotherapy Research, July 2014, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  5. Epigenetic Control of Autophagy by MicroRNAs in Ovarian Cancer

    Article • BioMed Research International, January 2014, Hindawi Publishing Corporation

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  6. Single Amino Acid Arginine Deprivation Triggers Prosurvival Autophagic Response in Ovarian Carcinoma SKOV3

    Article • BioMed Research International, January 2014, Hindawi Publishing Corporation

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  7. Expression and Clinical Significance of the Autophagy Proteins BECLIN 1 and LC3 in Ovarian Cancer

    Article • BioMed Research International, January 2014, Hindawi Publishing Corporation

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  8. Autophagy and thyroid carcinogenesis: genetic and epigenetic links

    Article • October 2013, Bioscientifica

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  9. Protection from UVB Toxicity in Human Keratinocytes by Thailand Native Herbs Extracts

    Article • Photochemistry and Photobiology, September 2013, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  10. Knockdown of cathepsin D in zebrafish fertilized eggs determines congenital myopathy

    Article • Bioscience Reports, April 2013, Portland Press Ltd.

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  11. Similarities and differences in the biogenesis, processing and lysosomal targeting between zebrafish and human pro-Cathepsin D: Functional implications

    Article • The International Journal of Biochemistry & Cell Biology, February 2013, Elsevier

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  12. Cathepsins: Getting in Shape for Lysosomal Proteolysis

    Article • January 2013, Springer Science + Business Media

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  13. Defective Autophagy in Parkinson’s Disease: Role of Oxidative Stress

    Article • Molecular Neurobiology, August 2012, Springer Science + Business Media

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  14. Dopamine induces apoptosis in APPswe-expressing Neuro2A cells following Pepstatin-sensitive proteolysis of APP in acid compartments

    Article • Brain Research, August 2012, Elsevier

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  15. Biocompatibility, endocytosis, and intracellular trafficking of mesoporous silica and polystyrene nanoparticles in ovarian cancer cells: effects of size and surface charge groups

    Article • International Journal of Nanomedicine, July 2012, Taylor & Francis

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  16. Labeling and exocytosis of secretory compartments in RBL mastocytes by polystyrene and mesoporous silica nanoparticles

    Article • International Journal of Nanomedicine, April 2012, Dove Medical Press

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  17. Involvement of autophagy in ovarian cancer: a working hypothesis

    Article • Journal of Ovarian Research, January 2012, Springer Science + Business Media

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  18. Induced autophagy reduces virus output in dengue infected monocytic cells

    Article • Virology, September 2011, Elsevier

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  19. Knock-Down of Cathepsin D Affects the Retinal Pigment Epithelium, Impairs Swim-Bladder Ontogenesis and Causes Premature Death in Zebrafish

    Article • PLoS ONE, July 2011, PLOS

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  20. Resveratrol Reduces the Invasive Growth and Promotes the Acquisition of a Long-Lasting Differentiated Phenotype in Human Glioblastoma Cells

    Article • Journal of Agricultural and Food Chemistry, April 2011, American Chemical Society (ACS)

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  21. Patented Biomarkers for the Early Detection of Ovarian Cancer

    Article • Recent Patents on Biomarkers, March 2011, Bentham Science Publishers

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  22. Autophagy-active beclin-1 correlates with favourable clinical outcome in non-Hodgkin lymphomas

    Article • Modern Pathology, May 2010, Springer Science + Business Media

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  23. Differential role of cathepsins B and L in autophagy-associated cell death induced by arsenic trioxide in U87 human glioblastoma cells

    Article • Biological Chemistry, May 2010, De Gruyter

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  24. High Expression of Cathepsin D in Non-Hodgkin’s Lymphomas Negatively Impacts on Clinical Outcome

    Article • Disease Markers, January 2010, Hindawi Publishing Corporation

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  25. Autophagy, lithium, and amyotrophic lateral sclerosis

    Article • Muscle & Nerve, July 2009, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  26. Chemotherapy drug response in ovarian cancer cells strictly depends on a cathepsin D-Bax activation loop

    Article • Journal of Cellular and Molecular Medicine, July 2009, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  27. Photoactive Hybrid Nanomaterials: Indocyanine Immobilized in Mesoporous MCM-41 for “In-Cell” Bioimaging

    Article • ACS Applied Materials & Interfaces, March 2009, American Chemical Society (ACS)

    Professor Ciro Isidoro, Dr Enrica Gianotti, Professor CIRO ISIDORO

  28. Serum and Intracellular Detection of Cytokines in Patients Undergoing Chronic Hemodialysis

    Article • Artificial Organs, November 2008, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  29. Role of Autophagy during Methamphetamine Neurotoxicity

    Article • Annals of the New York Academy of Sciences, October 2008, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  30. Prolactin Promotes the Secretion of Active Cathepsin D at the Basal Side of Rat Mammary Acini

    Article • Endocrinology, August 2008, Endocrine Society

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  31. Suppression of autophagy precipitates neuronal cell death following low doses of methamphetamine

    Article • Journal of Neurochemistry, August 2008, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  32. Autophagy and amyotrophic lateral sclerosis: The multiple roles of lithium

    Article • Autophagy, May 2008, Taylor & Francis

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  33. Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression

    Article • European Journal of Neuroscience, March 2008, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  34. A fast and simple method for simultaneous mixed site-specific mutagenesis of a wide coding sequence

    Article • Biotechnology and Applied Biochemistry, February 2008, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  35. Folding, activity and targeting of mutated human cathepsin D that cannot be processed into the double-chain form

    Article • The International Journal of Biochemistry & Cell Biology, January 2007, Elsevier

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  36. PI3K-dependent lysosome exocytosis in nitric oxide-preconditioned hepatocytes

    Article • Free Radical Biology and Medicine, May 2006, Elsevier

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  37. cFLIP expression correlates with tumour progression and patient outcome in non-Hodgkin lymphomas of low grade of malignancy

    Article • British Journal of Haematology, March 2006, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  38. High yield synthesis and characterization of phosphorylated recombinant human procathepsin D expressed in mammalian cells

    Article • Protein Expression and Purification, January 2006, Elsevier

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  39. Destination ‘Lysosome’: a target organelle for tumour cell killing?

    Article • Journal of Molecular Recognition, September 2003, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  40. Increase in Ceramide Level Alters the Lysosomal Targeting of Cathepsin D prior to Onset of Apoptosis in HT-29 Colon Cancer Cells

    Article • Biological Chemistry, January 2002, De Gruyter

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  41. Lysosomal proteases as potential targets for the induction of apoptotic cell death in human neuroblastomas

    Article • International Journal of Cancer, November 2001, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  42. Expression of protein kinase C ?1 confers resistance to TNF?- and paclitaxel-induced apoptosis in HT-29 colon carcinoma cells

    Article • International Journal of Cancer, January 2001, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  43. Transformation by oncogenic ras‐p21 alters the processing and subcellular localization of the lysosomal protease cathepsin D

    Article • Journal of Cellular Biochemistry, June 1999, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  44. Transformation by oncogenic ras-p21 alters the processing and subcellular localization of the lysosomal protease cathepsin D

    Article • Journal of Cellular Biochemistry, June 1999, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  45. Regulation of rat hepatocyte protein kinase C ? isoenzymes by the lipid peroxidation product 4-hydroxy-2,3-nonenal: A signaling pathway to modulate vesicular transport of glycoproteins

    Article • Hepatology, May 1999, Wiley

    Professor Ciro Isidoro, Professor Fiorella Biasi, Professor CIRO ISIDORO

  46. Lysosomal segregation of a mannose-rich glycoprotein imparted by the prosequence of myeloperoxidase

    Article • Journal of Cellular Biochemistry, November 1998, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  47. Differentiation-induced changes in the content, secretion, and subcellular distribution of lysosomal cathepsins in the human colon cancer HT-29 cell line

    Article • Cell and Tissue Research, June 1997, Springer Science + Business Media

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  48. Mis-sorting of procathepsin D in metastogenic tumor cells is not due to impaired synthesis of the phosphomannosyl signal

    Article • International Journal of Cancer, March 1997, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  49. Differential targeting and processing of procathepsin D in normal and transformed murine 3T3 fibroblasts

    Article • International Journal of Cancer, January 1997, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  50. Synthesis, maturation and extracellular release of procathepsin D as influenced by cell proliferation or transformation

    Article • International Journal of Cancer, December 1995, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  51. Altered intracellular processing and enhanced secretion of procathepsin D in a highly deviated rat hepatoma

    Article • International Journal of Cancer, January 1995, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  52. Effects of Calcitriol on the Biogenesis of a Lysosomal Protease in Monocytes from Patients with Renal Failure

    Article • January 1994, Karger Publishers

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  53. Role of monocytes in cryoglobulinemia-associated nephritis

    Article • Kidney International, May 1993, Elsevier

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  54. Altered transport and processing of cathepsin D in human tumour cells with metastatic phenotype

    Article • European Journal of Cancer and Clinical Oncology, January 1991, Elsevier

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  55. Suppression of the 'uncovering' of mannose-6-phosphate residues in lysosomal enzymes in the presence of NH4Cl

    Article • European Journal of Biochemistry, August 1990, Wiley

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  56. Brefeldin A Prevents Uncovering but not Phosphorylation of the Recognition Marker in Cathepsin D

    Article • Biological Chemistry Hoppe-Seyler, January 1990, De Gruyter

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  57. Regulation of Protein Degradation in Neoplastic Cells

    Article • January 1988, Springer Science + Business Media

    Professor Ciro Isidoro, Professor CIRO ISIDORO

  58. The transport of soluble lysosomal hydrolases from the Golgi complex to lysosomes

    Article • Springer Science + Business Media

    Professor Ciro Isidoro, Professor CIRO ISIDORO