All Stories

  1. Vitamin D (1,25(OH)2D3) induces α-1-antitrypsin synthesis by CD4+ T cells, which is required for 1,25(OH)2D3-driven IL-10

    Article • The Journal of Steroid Biochemistry and Molecular Biology, May 2019, Elsevier

    Catherine Hawrylowicz

  2. High-Dose IL-2 Skews a Glucocorticoid-Driven IL-17+IL-10+ Memory CD4+ T Cell Response towards a Single IL-10–Producing Phenotype

    Article • The Journal of Immunology, December 2018, The American Association of Immunologists

    Catherine Hawrylowicz

  3. Effects of vitamin D on inflammatory and oxidative stress responses of human bronchial epithelial cells exposed to particulate matter

    Article • PLoS ONE, August 2018, PLOS

    Catherine Hawrylowicz

  4. Exogenous sex steroid hormones and asthma in females: protocol for a population-based retrospective cohort study using a UK primary care database

    Article • BMJ Open, June 2018, BMJ

    Professor David Price, Professor Colin R Simpson, Catherine Hawrylowicz

  5. Vitamin D in Asthma

    Article • CHEST Journal, May 2018, Elsevier

    Catherine Hawrylowicz

  6. Vitamin D supplementation during pregnancy: Effect on the neonatal immune system in a randomized controlled trial

    Article • Journal of Allergy and Clinical Immunology, January 2018, Elsevier

    Catherine Hawrylowicz

  7. Dendritic cell phenotype in severe asthma reflects clinical responsiveness to glucocorticoids

    Article • Clinical & Experimental Allergy, December 2017, Wiley

    Catherine Hawrylowicz

  8. Urban particulate matter stimulation of human dendritic cells enhances priming of naive CD8 T lymphocytes

    Article • Immunology, November 2017, Wiley

    Catherine Hawrylowicz

  9. Vitamin D Counteracts an IL-23–Dependent IL-17A+IFN-γ+ Response Driven by Urban Particulate Matter

    Article • American Journal of Respiratory Cell and Molecular Biology, September 2017, American Thoracic Society

    Catherine Hawrylowicz

  10. Addressing unmet needs in understanding asthma mechanisms

    Article • European Respiratory Journal, May 2017, European Respiratory Society (ERS)

    Catherine Hawrylowicz

  11. Activin-A co-opts IRF4 and AhR signaling to induce human regulatory T cells that restrain asthmatic responses

    Article • Proceedings of the National Academy of Sciences, March 2017, Proceedings of the National Academy of Sciences

    Catherine Hawrylowicz

  12. Interleukin 10 inhibits pro-inflammatory cytokine responses and killing of Burkholderia pseudomallei

    Article • Scientific Reports, February 2017, Springer Science + Business Media

    Catherine Hawrylowicz

  13. ASTHMA – comparing the impact of vitamin D versus UVR on clinical and immune parameters

    Article • Photochemical & Photobiological Sciences, January 2017, Springer Science + Business Media

    Catherine Hawrylowicz

  14. Urban Particulate Matter–Activated Human Dendritic Cells Induce the Expansion of Potent Inflammatory Th1, Th2, and Th17 Effector Cells

    Article • American Journal of Respiratory Cell and Molecular Biology, February 2016, American Thoracic Society

    Catherine Hawrylowicz

  15. Effect of Prenatal Supplementation With Vitamin D on Asthma or Recurrent Wheezing in Offspring by Age 3 Years

    Article • JAMA, January 2016, American Medical Association (AMA)

    Catherine Hawrylowicz

  16. 1α,25-dihydroxyvitamin D3 acts via transforming growth factor-βto up-regulate expression of immunosuppressive CD73 on human CD4+Foxp3-T cells

    Article • Immunology, September 2015, Wiley

    Catherine Hawrylowicz

  17. Distinct endotypes of steroid-resistant asthma characterized by IL-17Ahigh and IFN-γhigh immunophenotypes: Potential benefits of calcitriol

    Article • Journal of Allergy and Clinical Immunology, September 2015, Elsevier

    Catherine Hawrylowicz

  18. A comparative phase 1 clinical trial to identify anti-infective mechanisms of vitamin D in people with HIV infection

    Article • AIDS, June 2015, Wolters Kluwer Health

    Catherine Hawrylowicz

  19. Vitamin D enhances production of soluble ST2, inhibiting the action of IL-33

    Article • Journal of Allergy and Clinical Immunology, March 2015, Elsevier

    Catherine Hawrylowicz

  20. Double-blind randomised placebo-controlled trial of bolus-dose vitamin D3supplementation in adults with asthma (ViDiAs)

    Article • Thorax, February 2015, BMJ

    Catherine Hawrylowicz, Angshu Bhowmik

  21. Vitamin D3 supplementation in patients with chronic obstructive pulmonary disease (ViDiCO): a multicentre, double-blind, randomised controlled trial

    Article • The Lancet Respiratory Medicine, February 2015, Elsevier

    Catherine Hawrylowicz, Angshu Bhowmik

  22. Vitamin D Influences Asthmatic Pathology through Its Action on Diverse Immunological Pathways

    Article • Annals of the American Thoracic Society, December 2014, American Thoracic Society

    Catherine Hawrylowicz

  23. Developments in the field of allergy in 2013 through the eyes of Clinical and Experimental Allergy

    Article • Clinical & Experimental Allergy, November 2014, Wiley

    Catherine Hawrylowicz

  24. Vitamin D deficiency induces Th2 skewing and eosinophilia in neonatal allergic airways disease

    Article • Allergy, August 2014, Wiley

    Catherine Hawrylowicz

  25. 1α,25-dihydroxyvitamin D3 in combination with transforming growth factor-βincreases the frequency of Foxp3+regulatory T cells through preferential expansion and usage of interleukin-2

    Article • Immunology, July 2014, Wiley

    Catherine Hawrylowicz

  26. The effects of calcitriol treatment in glucocorticoid-resistant asthma

    Article • Journal of Allergy and Clinical Immunology, June 2014, Elsevier

    Catherine Hawrylowicz

  27. Immunoregulatory mechanisms of vitamin D relevant to respiratory health and asthma

    Article • Annals of the New York Academy of Sciences, April 2014, Wiley

    Catherine Hawrylowicz

  28. Depigmented-polymerised allergoids favour regulatory over effector T cells: enhancement by 1α, 25-dihydroxyvitamin D3

    Article • BMC Immunology, January 2014, Springer Science + Business Media

    Catherine Hawrylowicz

  29. Defective IL-10 expression and in vitro steroid-induced IL-17A in paediatric severe therapy-resistant asthma

    Article • Thorax, December 2013, BMJ

    Catherine Hawrylowicz

  30. Urban Particulate Matter Suppresses Priming of Th1 Cells by GM-CSF-Activated Human Dendritic Cells

    Article • American Journal of Respiratory Cell and Molecular Biology, September 2013, American Thoracic Society

    Catherine Hawrylowicz

  31. Enhanced production of IL-17A in patients with severe asthma is inhibited by 1α,25-dihydroxyvitamin D3 in a glucocorticoid-independent fashion

    Article • Journal of Allergy and Clinical Immunology, August 2013, Elsevier

    Catherine Hawrylowicz

  32. Vitamin D and Asthma in Children

    Article • Paediatric Respiratory Reviews, December 2012, Elsevier

    Catherine Hawrylowicz

  33. Vitamin D and lung disease

    Article • Thorax, August 2012, BMJ

    Catherine Hawrylowicz

  34. The role of 1α,25-dihydroxyvitamin D3 and cytokines in the promotion of distinct Foxp3+and IL-10+CD4+T cells

    Article • European Journal of Immunology, August 2012, Wiley

    Catherine Hawrylowicz

  35. Serum 25-dihydroxyvitamin D levels correlate with CD4+Foxp3+ T-cell numbers in moderate/severe asthma

    Article • Journal of Allergy and Clinical Immunology, August 2012, Elsevier

    Catherine Hawrylowicz

  36. T cells producing the anti-inflammatory cytokine IL-10 regulate allergen-specific Th2 responses in human airways

    Article • Allergy, June 2012, Wiley

    Catherine Hawrylowicz, A/Professor Narinder Pal Singh

  37. Glucocorticosteroids Are Potential Confounders in Studies of Vitamin D and Asthma: Reply

    Article • American Journal of Respiratory and Critical Care Medicine, June 2012, American Thoracic Society

    Catherine Hawrylowicz

  38. Vitamin D binding protein and asthma severity in children

    Article • Journal of Allergy and Clinical Immunology, June 2012, Elsevier

    Catherine Hawrylowicz

  39. 1α,25-Dihydroxyvitamin D3 promotes CD200 expression by human peripheral and airway-resident T cells

    Article • Thorax, February 2012, BMJ

    Catherine Hawrylowicz

  40. Vitamin D and Regulatory T Cells

    Article • January 2012, Springer Science + Business Media

    Catherine Hawrylowicz

  41. Relationship between Serum Vitamin D, Disease Severity, and Airway Remodeling in Children with Asthma

    Article • American Journal of Respiratory and Critical Care Medicine, December 2011, American Thoracic Society

    Catherine Hawrylowicz

  42. A randomized placebo-controlled trial of rush preseasonal depigmented polymerized grass pollen immunotherapy*

    Article • Allergy, November 2011, Wiley

    Catherine Hawrylowicz

  43. Comprehensive genetic assessment of a functional TLR9 promoter polymorphism: no replicable association with asthma or asthma-related phenotypes

    Article • BMC Medical Genetics, February 2011, Springer Science + Business Media

    Catherine Hawrylowicz

  44. A direct role for vitamin D-binding protein in the pathogenesis of COPD?

    Article • Thorax, January 2011, BMJ

    Catherine Hawrylowicz

  45. The Impact of Vitamin D on Regulatory T Cells

    Article • Current Allergy and Asthma Reports, November 2010, Springer Science + Business Media

    Catherine Hawrylowicz

  46. A novel technique to explore the functions of bronchial mucosal T cells in chronic obstructive pulmonary disease: application to cytotoxicity and cytokine immunoreactivity

    Article • Clinical & Experimental Immunology, August 2010, Wiley

    Catherine Hawrylowicz

  47. Regulatory T cells, inflammation and the allergic response—The role of glucocorticoids and Vitamin D

    Article • The Journal of Steroid Biochemistry and Molecular Biology, May 2010, Elsevier

    Catherine Hawrylowicz

  48. Asthma and allergy: The early beginnings

    Article • Nature Medicine, March 2010, Springer Science + Business Media

    Catherine Hawrylowicz

  49. Vitamin D, the immune system and asthma

    Article • Expert Review of Clinical Immunology, November 2009, Taylor & Francis

    Catherine Hawrylowicz

  50. Regulatory T Cells in Asthma

    Article • Immunity, September 2009, Elsevier

    Catherine Hawrylowicz

  51. Vitamin D and Asthma

    Article • American Journal of Respiratory and Critical Care Medicine, May 2009, American Thoracic Society

    Catherine Hawrylowicz

  52. Counter regulation of the high affinity IgE receptor, FcεRI, on human airway dendritic cells by IL-4 and IL-10

    Article • Allergy, April 2009, Wiley

    Catherine Hawrylowicz, A/Professor Narinder Pal Singh

  53. Regulatory T cells in bronchial asthma

    Article • Allergy, March 2009, Wiley

    Catherine Hawrylowicz

  54. Ligation of TLR9 induced on human IL-10–secreting Tregs by 1α,25-dihydroxyvitamin D3 abrogates regulatory function

    Article • Journal of Clinical Investigation, January 2009, American Society for Clinical Investigation

    Catherine Hawrylowicz

  55. Strategies for use of IL-10 or its antagonists in human disease

    Article • Immunological Reviews, June 2008, Wiley

    Catherine Hawrylowicz

  56. Role of cysteinyl leukotrienes in human allergen-specific Th2 responses induced by granulocyte macrophage-colony stimulating factor

    Article • Allergy, January 2008, Wiley

    Catherine Hawrylowicz

  57. The glucocorticoid receptor β isoform can mediate transcriptional repression by recruiting histone deacetylases

    Article • Journal of Allergy and Clinical Immunology, January 2008, Elsevier

    Catherine Hawrylowicz

  58. Regulatory T cell therapy as individualized medicine for asthma and allergy

    Article • Current Opinion in Allergy and Clinical Immunology, December 2007, Wolters Kluwer Health

    Catherine Hawrylowicz

  59. Plasmacytoid Dendritic Cells from Human Lung Cancer Draining Lymph Nodes Induce Tc1 Responses

    Article • American Journal of Respiratory Cell and Molecular Biology, March 2007, American Thoracic Society

    Catherine Hawrylowicz

  60. Immunological intervention in human diseases

    Article • Journal of Translational Medicine, January 2007, Springer Science + Business Media

    Catherine Hawrylowicz

  61. Interleukin-10-Secreting regulatory T cells in allergy and asthma

    Article • Current Allergy and Asthma Reports, September 2006, Springer Science + Business Media

    Catherine Hawrylowicz

  62. Regulatory T cells in human disease and their potential for therapeutic manipulation

    Article • Immunology, May 2006, Wiley

    Catherine Hawrylowicz

  63. Vitamin D3 in inflammatory airway disease and immunosuppression

    Article • Drug Discovery Today Disease Mechanisms, March 2006, Elsevier

    Catherine Hawrylowicz

  64. T regulatory cells and the control of allergic disease

    Article • Expert Opinion on Biological Therapy, January 2006, Informa Healthcare

    Catherine Hawrylowicz

  65. Effector Cells of Allergy

    Article • January 2006, Elsevier

    Catherine Hawrylowicz

  66. Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients

    Article • Journal of Clinical Investigation, December 2005, American Society for Clinical Investigation

    Catherine Hawrylowicz

  67. Regulatory T cells and IL-10 in allergic inflammation: Figure. 1.

    Article • The Journal of Experimental Medicine, December 2005, Rockefeller University Press

    Catherine Hawrylowicz

  68. Functional plasticity of human respiratory tract dendritic cells: GM-CSF enhances TH2 development

    Article • Journal of Allergy and Clinical Immunology, November 2005, Elsevier

    Catherine Hawrylowicz

  69. Interleukin-10–Secreting “Regulatory” T Cells Induced by Glucocorticoids and β2-Agonists

    Article • American Journal of Respiratory Cell and Molecular Biology, July 2005, American Thoracic Society

    Catherine Hawrylowicz

  70. Repression ofInterleukin-5Transcription by the Glucocorticoid Receptor Targets GATA3 Signaling and Involves Histone Deacetylase Recruitment

    Article • Journal of Biological Chemistry, April 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Catherine Hawrylowicz

  71. Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma

    Article • Nature Reviews Immunology, March 2005, Springer Science + Business Media

    Catherine Hawrylowicz

  72. Targeting the dendritic cell: the key to immunotherapy in cancer?

    Article • Clinical & Experimental Immunology, March 2005, Wiley

    Catherine Hawrylowicz

  73. Glucocorticoid-resistant asthma

    Article • Clinical & Experimental Allergy Reviews, December 2004, Wiley

    Catherine Hawrylowicz

  74. Impaired secretion of interleukin-4 and interleukin-13 by allergen-specific T cells correlates with defective nuclear expression of NF-AT2 and jun B: relevance to immunotherapy

    Article • Clinical & Experimental Allergy, September 2003, Wiley

    Catherine Hawrylowicz

  75. In Vitro Generation of Interleukin 10–producing Regulatory CD4+T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines

    Article • The Journal of Experimental Medicine, March 2002, Rockefeller University Press

    Catherine Hawrylowicz

  76. A defect in corticosteroid-induced IL-10 production in T lymphocytes from corticosteroid-resistant asthmatic patients

    Article • Journal of Allergy and Clinical Immunology, February 2002, Elsevier

    Catherine Hawrylowicz

  77. CXCR4 expression on monocytes is up-regulated by dexamethasone and is modulated by autologous CD3+ T cells

    Article • Immunology, February 2002, Wiley

    Catherine Hawrylowicz

  78. Discussion session II: Inflammation

    Article • Clinical & Experimental Allergy Reviews, July 2001, Wiley

    Catherine Hawrylowicz

  79. Monocytes and macrophages - friend or foe?

    Article • Clinical & Experimental Allergy Reviews, July 2001, Wiley

    Catherine Hawrylowicz

  80. Regulation of major histocompatibility complex class II antigens on human alveolar macrophages by granulocyte-macrophage colony-stimulating factor in the presence of glucocorticoids

    Article • Immunology, September 1999, Wiley

    Catherine Hawrylowicz

  81. Methotrexate inhibits the first committed step of purine biosynthesis in mitogen-stimulated human T-lymphocytes: a metabolic basis for efficacy in rheumatoid arthritis?

    Article • Biochemical Journal, August 1999, Portland Press Ltd.

    Catherine Hawrylowicz

  82. Leflunomide Inhibits Pyrimidinede NovoSynthesis in Mitogen-stimulated T-lymphocytes from Healthy Humans

    Article • Journal of Biological Chemistry, August 1998, American Society for Biochemistry & Molecular Biology (ASBMB)

    Catherine Hawrylowicz

  83. A Mutation in the Interferon-γ –Receptor Gene and Susceptibility to Mycobacterial Infection

    Article • New England Journal of Medicine, December 1996, New England Journal of Medicine (NEJM/MMS)

    Catherine Hawrylowicz

  84. T-cell receptor peptides that inhibit the T-cell response to allergen induce transforming growth factor-β production

    Article • Journal of Allergy and Clinical Immunology, February 1996, Elsevier

    Catherine Hawrylowicz

  85. Inhibition of human T-cell responses to house dust mite allergens by a T-cell receptor peptide

    Article • Journal of Allergy and Clinical Immunology, November 1994, Elsevier

    Catherine Hawrylowicz

  86. Viewpoint: A Potential Role for Platelet Derived Cytokines in the Inflammatory Response

    Article • Platelets, January 1993, Taylor & Francis

    Catherine Hawrylowicz

  87. Synergism of glucocorticoids with granulocyte macrophage colony stimulating factor (GM-CSF) but not interferon gamma (IFN-γ) or interleukin-4 (IL-4) on induction of HLA class II expression on human monocytes

    Article • Cytokine, July 1992, Elsevier

    Catherine Hawrylowicz

  88. Cell-cycle control in lymphocyte stimulation

    Article • Immunology Today, January 1984, Elsevier

    Catherine Hawrylowicz

  89. Human spleen cells mediating natural killing: Altered natural cytotoxicity of spleen effector cells from patients with carcinoma

    Article • Journal of Cancer Research and Clinical Oncology, December 1983, Springer Science + Business Media

    Catherine Hawrylowicz

  90. Depressed spontaneous natural killing and interferon augmentation in patients with malignant lymphoma

    Article • European Journal of Cancer and Clinical Oncology, November 1982, Elsevier

    Catherine Hawrylowicz

  91. Regulatory T Cells and Other Tolerogenic Mechanisms in Allergy and Asthma

    Article • Wiley

    Catherine Hawrylowicz