All Stories

  1. Repeated binge‐like eating episodes in female rats alter adenosine A2A and dopamine D2 receptor genes regulation in the brain reward system

    Article • International Journal of Eating Disorders, April 2024, Wiley

    Carlo Cifani

  2. Novel rat model of gaming disorder: assessment of social reward and sex differences in behavior and c-Fos brain activity

    Article • Psychopharmacology, April 2024, Springer Science + Business Media

    Carlo Cifani

  3. Dysfunction of the Brown Adipose Organ in HFD-Obese Rats and Effect of Tart Cherry Supplementation

    Article • Antioxidants, March 2024, MDPI AG

    Carlo Cifani

  4. Evaluating the efficacy of the selective orexin 1 receptor antagonist nivasorexant in an animal model of binge‐eating disorder

    Article • International Journal of Eating Disorders, March 2024, Wiley

    Carlo Cifani

  5. Anti-Glycation Properties of Zinc-Enriched Arthrospira platensis (Spirulina) Contribute to Prevention of Metaflammation in a Diet-Induced Obese Mouse Model

    Article • Nutrients, February 2024, MDPI AG

    Carlo Cifani

  6. Administration of Linoleoylethanolamide Reduced Weight Gain, Dyslipidemia, and Inflammation Associated with High-Fat-Diet-Induced Obesity

    Article • Nutrients, October 2023, MDPI AG

    Carlo Cifani

  7. GABAergic miR-34a regulates Dorsal Raphè inhibitory transmission in response to aversive, but not rewarding, stimuli

    Article • Proceedings of the National Academy of Sciences, July 2023, Proceedings of the National Academy of Sciences

    Carlo Cifani, Diego Andolina

  8. The Neuromedin U system: pharmacological implications for the treatment of obesity and binge eating behavior

    Article • Pharmacological Research, July 2023, Elsevier

    Carlo Cifani

  9. Targeting orexin receptors: Recent advances in the development of subtype selective or dual ligands for the treatment of neuropsychiatric disorders

    Article • Medicinal Research Reviews, April 2023, Wiley

    Carlo Cifani

  10. SYNBIO® Probiotic and Antioxidant Dietary Supplementation: Clinical Trial Evaluation of Potential Effects on Airline Flight Crew Members’ Well-Being

    Article • Microorganisms, April 2023, MDPI AG

    Carlo Cifani

  11. Six-Month Synbio® Administration Affects Nutritional and Inflammatory Parameters of Older Adults Included in the PROBIOSENIOR Project

    Article • Microorganisms, March 2023, MDPI AG

    Carlo Cifani

  12. Anxiety associated with palatable food withdrawal is reversed by the selective FAAH inhibitor PF ‐3845: A regional analysis of the contribution of endocannabinoid signaling machinery

    Article • International Journal of Eating Disorders, February 2023, Wiley

    Carlo Cifani

  13. Involvement of miR-135a-5p Downregulation in Acute and Chronic Stress Response in the Prefrontal Cortex of Rats

    Article • International Journal of Molecular Sciences, January 2023, MDPI AG

    Carlo Cifani

  14. Endocannabinoid System Regulation in Female Rats with Recurrent Episodes of Binge Eating

    Article • International Journal of Molecular Sciences, December 2022, MDPI AG

    Carlo Cifani

  15. Impact of a probiotic diet on wellbeing of healthy senior: THE PROBIOSENIOR PROJECT

    Article • Journal of Applied Microbiology, July 2022, Wiley

    Carlo Cifani

  16. A Role for Neuropeptide S in Alcohol and Cocaine Seeking

    Article • Pharmaceuticals, June 2022, MDPI AG

    Carlo Cifani

  17. Anti-Inflammatory and Antioxidant Properties of Tart Cherry Consumption in the Heart of Obese Rats

    Article • Biology, April 2022, MDPI AG

    Carlo Cifani

  18. Obesity-Related Brain Cholinergic System Impairment in High-Fat-Diet-Fed Rats

    Article • Nutrients, March 2022, MDPI AG

    Carlo Cifani

  19. Advances in the Development of Nonpeptide Small Molecules Targeting Ghrelin Receptor

    Article • Journal of Medicinal Chemistry, February 2022, American Chemical Society (ACS)

    Carlo Cifani

  20. A New NF-κB Inhibitor, MEDS-23, Reduces the Severity of Adverse Post-Ischemic Stroke Outcomes in Rats

    Article • Brain Sciences, December 2021, MDPI AG

    Carlo Cifani

  21. Role of Nociceptin/Orphanin FQ-NOP Receptor System in the Regulation of Stress-Related Disorders

    Article • International Journal of Molecular Sciences, November 2021, MDPI AG

    Carlo Cifani

  22. Ion channels alterations in the forebrain of high-fat diet fed rats

    Article • European Journal of Histochemistry, November 2021, PAGEPress Publications

    Carlo Cifani

  23. Supplementation with Lactiplantibacillus plantarum IMC 510 Modifies Microbiota Composition and Prevents Body Weight Gain Induced by Cafeteria Diet in Rats

    Article • International Journal of Molecular Sciences, October 2021, MDPI AG

    Carlo Cifani

  24. Assessing the role of ghrelin and the enzyme ghrelin O-acyltransferase (GOAT) system in food reward, food motivation, and binge eating behavior

    Article • Pharmacological Research, October 2021, Elsevier

    Carlo Cifani

  25. Natural Antioxidant Application on Fat Accumulation: Preclinical Evidence

    Article • Antioxidants, May 2021, MDPI AG

    Carlo Cifani

  26. The Neural Network of Neuropeptide S (NPS): Implications in Food Intake and Gastrointestinal Functions

    Article • Pharmaceuticals, March 2021, MDPI AG

    Carlo Cifani

  27. Tart Cherry Juice and Seeds Affect Pro-Inflammatory Markers in Visceral Adipose Tissue of High-Fat Diet Obese Rats

    Article • Molecules, March 2021, MDPI AG

    Carlo Cifani

  28. Cannabidiol as a Potential Treatment for Anxiety and Mood Disorders: Molecular Targets and Epigenetic Insights from Preclinical Research

    Article • International Journal of Molecular Sciences, February 2021, MDPI AG

    Carlo Cifani

  29. Recent findings leading to the discovery of selective dopamine D4 receptor ligands for the treatment of widespread diseases

    Article • European Journal of Medicinal Chemistry, February 2021, Elsevier

    Carlo Cifani

  30. Serum metabolic signature of binge‐like palatable food consumption in female rats by nuclear magnetic resonance spectroscopy

    Article • NMR in Biomedicine, January 2021, Wiley

    Carlo Cifani, Dr Silvia Alboni

  31. On the Role of Central Type-1 Cannabinoid Receptor Gene Regulation in Food Intake and Eating Behaviors

    Article • International Journal of Molecular Sciences, January 2021, MDPI AG

    Carlo Cifani

  32. The Melanocortin System behind the Dysfunctional Eating Behaviors

    Article • Nutrients, November 2020, MDPI AG

    Carlo Cifani

  33. Genetic and epigenetic architecture of Obsessive-Compulsive Disorder: in search of possible diagnostic and prognostic biomarkers

    Article • Journal of Psychiatric Research, November 2020, Elsevier

    Carlo Cifani

  34. Novel Highly Potent and Selective Sigma1 Receptor Antagonists Effectively Blocking the Binge Eating Episode in Female Rats

    Article • ACS Chemical Neuroscience, September 2020, American Chemical Society (ACS)

    Carlo Cifani

  35. Effects of Exogenous Dietary Advanced Glycation End Products on the Cross-Talk Mechanisms Linking Microbiota to Metabolic Inflammation

    Article • Nutrients, August 2020, MDPI AG

    Carlo Cifani, Dr Kieran M Tuohy

  36. Underlying Susceptibility to Eating Disorders and Drug Abuse: Genetic and Pharmacological Aspects of Dopamine D4 Receptors

    Article • Nutrients, July 2020, MDPI AG

    Carlo Cifani

  37. Oxytocin in the neural control of eating: At the crossroad between homeostatic and non-homeostatic signals

    Article • Neuropharmacology, July 2020, Elsevier

    Carlo Cifani

  38. Obesity and Age-Related Changes in the Brain of the Zucker Lepr fa/fa Rats

    Article • Nutrients, May 2020, MDPI AG

    Carlo Cifani

  39. Effects of Prunus cerasus L. Seeds and Juice on Liver Steatosis in an Animal Model of Diet-Induced Obesity

    Article • Nutrients, May 2020, MDPI AG

    Carlo Cifani

  40. Xlr4 as a new candidate gene underlying vulnerability to cocaine effects

    Article • Neuropharmacology, May 2020, Elsevier

    Carlo Cifani

  41. Oleoylethanolamide decreases frustration stress-induced binge-like eating in female rats: a novel potential treatment for binge eating disorder

    Article • Neuropsychopharmacology, April 2020, Springer Science + Business Media

    Carlo Cifani

  42. Epigenetic regulation of the cannabinoid receptor CB1 in an activity-based rat model of anorexia nervosa

    Article • International Journal of Eating Disorders, April 2020, Wiley

    Carlo Cifani

  43. Cardiovascular Changes Related to Metabolic Syndrome: Evidence in Obese Zucker Rats

    Article • International Journal of Molecular Sciences, March 2020, MDPI AG

    Carlo Cifani

  44. Modulation of Pain Sensitivity by Chronic Consumption of Highly Palatable Food Followed by Abstinence: Emerging Role of Fatty Acid Amide Hydrolase

    Article • Frontiers in Pharmacology, March 2020, Frontiers

    Carlo Cifani

  45. Brain Alterations in High Fat Diet Induced Obesity: Effects of Tart Cherry Seeds and Juice

    Article • Nutrients, February 2020, MDPI AG

    Carlo Cifani

  46. Role of Projections between Piriform Cortex and Orbitofrontal Cortex in Relapse to Fentanyl Seeking after Palatable Food Choice-Induced Voluntary Abstinence

    Article • Journal of Neuroscience, February 2020, Society for Neuroscience

    Carlo Cifani

  47. Effects of chronic silencing of relaxin-3 production in nucleus incertus neurons on food intake, body weight, anxiety-like behaviour and limbic brain activity in female rats

    Article • Psychopharmacology, January 2020, Springer Science + Business Media

    Carlo Cifani

  48. MALDI-Mass Spectrometry Imaging to Investigate Lipid and Bile Acid Modifications Caused by Lentil Extract Used as a Potential Hypocholesterolemic Treatment

    Article • Journal of the American Society for Mass Spectrometry, August 2019, Springer Science + Business Media

    Carlo Cifani

  49. Investigation of the Role of Chirality in the Interaction with σ Receptors and Effect on Binge Eating Episode of a Potent σ1 Antagonist Analogue of Spipethiane

    Article • ACS Chemical Neuroscience, July 2019, American Chemical Society (ACS)

    Carlo Cifani

  50. Preclinical and Clinical Evidence for a Distinct Regulation of Mu Opioid and Type 1 Cannabinoid Receptor Genes Expression in Obesity

    Article • Frontiers in Genetics, June 2019, Frontiers

    Carlo Cifani

  51. Regulation of adenosine A2A receptor gene expression in a model of binge eating in the amygdaloid complex of female rats

    Article • Journal of Psychopharmacology, June 2019, SAGE Publications

    Carlo Cifani

  52. N/OFQ-NOP System in Food Intake

    Article • January 2019, Springer Science + Business Media

    Carlo Cifani

  53. Transcriptional regulation of the endocannabinoid system in a rat model of binge-eating behavior reveals a selective modulation of the hypothalamic fatty acid amide hydrolase gene

    Article • International Journal of Eating Disorders, December 2018, Wiley

    Carlo Cifani

  54. Gene expression profiling in adipose tissue of Sprague Dawley rats identifies olfactory receptor 984 as a potential obesity treatment target

    Article • Biochemical and Biophysical Research Communications, November 2018, Elsevier

    Carlo Cifani

  55. Environmental stressors and alcoholism development: Focus on molecular targets and their epigenetic regulation

    Article • Neuroscience & Biobehavioral Reviews, July 2018, Elsevier

    Carlo Cifani

  56. 1-[3-(4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1) as a Model for the Rational Design of a Novel Class of Brain Penetrant Ligands with High Affinity and Selectivity for Dopamine D4 Receptor

    Article • Journal of Medicinal Chemistry, March 2018, American Chemical Society (ACS)

    Carlo Cifani

  57. The Anterior Insular Cortex→Central Amygdala Glutamatergic Pathway Is Critical to Relapse after Contingency Management

    Article • Neuron, October 2017, Elsevier

    Carlo Cifani

  58. Roles of Hospital and Territorial Pharmacists within the Italian National Healthcare Service

    Article • The Canadian Journal of Hospital Pharmacy, August 2017, Canadian Society of Hospital Pharmacists (CSHP)

    Carlo Cifani

  59. Evaluation of the hypocholesterolemic effect and prebiotic activity of a lentil (Lens culinaris Medik) extract

    Article • Molecular Nutrition & Food Research, August 2017, Wiley

    Carlo Cifani

  60. Hypothalamic CRF1 receptor mechanisms are not sufficient to account for binge-like palatable food consumption in female rats

    Article • International Journal of Eating Disorders, August 2017, Wiley

    Carlo Cifani

  61. Role of the area postrema in the hypophagic effects of oleoylethanolamide

    Article • Pharmacological Research, August 2017, Elsevier

    Carlo Cifani

  62. Context-induced relapse to cocaine seeking after punishment-imposed abstinence is associated with activation of cortical and subcortical brain regions

    Article • Addiction Biology, June 2017, Wiley

    Carlo Cifani, Yavin Shaham

  63. Genetic variation and epigenetic modification of the prodynorphin gene in peripheral blood cells in alcoholism

    Article • Progress in Neuro-Psychopharmacology and Biological Psychiatry, June 2017, Elsevier

    Carlo Cifani

  64. Hypothalamic expression of inflammatory mediators in an animal model of binge eating

    Article • Behavioural Brain Research, March 2017, Elsevier

    Carlo Cifani

  65. Estrogenic suppression of binge-like eating elicited by cyclic food restriction and frustrative-nonreward stress in female rats

    Article • International Journal of Eating Disorders, February 2017, Wiley

    Carlo Cifani

  66. Effects of [Nphe1, Arg14, Lys15] N/OFQ-NH2 (UFP-101), a potent NOP receptor antagonist, on molecular, cellular and behavioural alterations associated with chronic mild stress

    Article • Journal of Psychopharmacology, January 2017, SAGE Publications

    Carlo Cifani

  67. The replacement of the 2-methoxy substituent of N-((6,6-diphenyl-1,4-dioxan-2-yl)methyl)-2-(2-methoxyphenoxy)ethan-1-amine improves the selectivity for 5-HT1A receptor over α1-adrenoceptor and D2-like receptor subtypes

    Article • European Journal of Medicinal Chemistry, January 2017, Elsevier

    Carlo Cifani

  68. Neuropeptide S differently modulates alcohol-related behaviors in alcohol-preferring and non-preferring rats

    Article • Psychopharmacology, May 2016, Springer Science + Business Media

    Carlo Cifani

  69. Amylin receptor components and the leptin receptor are co-expressed in single rat area postrema neurons

    Article • European Journal of Neuroscience, February 2016, Wiley

    Carlo Cifani

  70. Epigenetic regulation of nociceptin/orphanin FQ and corticotropin-releasing factor system genes in frustration stress-induced binge-like palatable food consumption

    Article • Addiction Biology, September 2015, Wiley

    Carlo Cifani

  71. Regulation of hypothalamic neuropeptides gene expression in diet induced obesity resistant rats: possible targets for obesity prediction?

    Article • Frontiers in Neuroscience, June 2015, Frontiers

    Carlo Cifani

  72. Antagonism/Agonism Modulation to Build Novel Antihypertensives Selectively Triggering I1-Imidazoline Receptor Activation

    Article • ACS Medicinal Chemistry Letters, April 2015, American Chemical Society (ACS)

    Carlo Cifani

  73. Extravirgin olive oil up-regulates CB1 tumor suppressor gene in human colon cancer cells and in rat colon via epigenetic mechanisms

    Article • The Journal of Nutritional Biochemistry, March 2015, Elsevier

    Carlo Cifani

  74. Inhibition of anandamide hydrolysis enhances noradrenergic and GABAergic transmission in the prefrontal cortex and basolateral amygdala of rats subjected to acute swim stress

    Article • Journal of Neuroscience Research, January 2015, Wiley

    Carlo Cifani

  75. Endocannabinoid signaling and food addiction

    Article • Neuroscience & Biobehavioral Reviews, November 2014, Elsevier

    Carlo Cifani

  76. Depressive-Like Behavior Is Paired to Monoaminergic Alteration in a Murine Model of Alzheimer's Disease

    Article • The International Journal of Neuropsychopharmacology, October 2014, Oxford University Press (OUP)

    Carlo Cifani

  77. Role of the basolateral amygdala in mediating the effects of the fatty acid amide hydrolase inhibitor URB597 on HPA axis response to stress

    Article • European Neuropsychopharmacology, September 2014, Elsevier

    Carlo Cifani

  78. Role of Bed Nucleus of the Stria Terminalis Corticotrophin-Releasing Factor Receptors in Frustration Stress-Induced Binge-Like Palatable Food Consumption in Female Rats with a History of Food Restriction

    Article • Journal of Neuroscience, August 2014, Society for Neuroscience

    Carlo Cifani

  79. Functional antagonism between nociceptin/orphanin FQ and corticotropin-releasing factor in rat anxiety-related behaviors: Involvement of the serotonergic system

    Article • Neuropeptides, August 2014, Elsevier

    Carlo Cifani

  80. Caloric restriction increases the sensitivity to the hyperphagic effect of nociceptin/orphanin FQ limiting its ability to reduce binge eating in female rats

    Article • Psychopharmacology, March 2013, Springer Science + Business Media

    Carlo Cifani

  81. A2A adenosine receptor agonists reduce both high-palatability and low-palatability food intake in female rats

    Article • Behavioural Pharmacology, September 2012, Wolters Kluwer Health

    Carlo Cifani

  82. Binge Eating in Female Rats Induced by Yo-Yo Dieting and Stress

    Article • August 2012, Springer Science + Business Media

    Carlo Cifani

  83. Medial Prefrontal Cortex Neuronal Activation and Synaptic Alterations after Stress-Induced Reinstatement of Palatable Food Seeking: A Study Using c-fos-GFP Transgenic Female Rats

    Article • Journal of Neuroscience, June 2012, Society for Neuroscience

    Carlo Cifani

  84. Role of Orexin-1 Receptor Mechanisms on Compulsive Food Consumption in a Model of Binge Eating in Female Rats

    Article • Neuropsychopharmacology, May 2012, Springer Science + Business Media

    Carlo Cifani

  85. Effect ofHypericum perforatumExtract in an Experimental Model of Binge Eating in Female Rats

    Article • Journal of Obesity, January 2012, Hindawi Publishing Corporation

    Carlo Cifani

  86. Effect of fenfluramine on reinstatement of food seeking in female and male rats: implications for the predictive validity of the reinstatement model

    Article • Psychopharmacology, December 2011, Springer Science + Business Media

    Carlo Cifani

  87. Effects of A2A adenosine receptor blockade or stimulation on alcohol intake in alcohol-preferring rats

    Article • Psychopharmacology, August 2011, Springer Science + Business Media

    Carlo Cifani

  88. Ventral medial prefrontal cortex neuronal ensembles mediate context-induced relapse to heroin

    Article • Nature Neuroscience, February 2011, Springer Science + Business Media

    Carlo Cifani

  89. Effect of prazosin and guanfacine on stress-induced reinstatement of alcohol and food seeking in rats

    Article • Psychopharmacology, February 2011, Springer Science + Business Media

    Carlo Cifani

  90. Effect of neuropeptide S receptor antagonists and partial agonists on palatable food consumption in the rat

    Article • Peptides, January 2011, Elsevier

    Carlo Cifani

  91. Effect of salidroside, active principle of Rhodiola rosea extract, on binge eating

    Article • Physiology & Behavior, December 2010, Elsevier

    Carlo Cifani

  92. Gender differences in Nociceptin/Orphanin FQ-induced food intake in strains derived from rats prone (WOKW) and resistant (Dark Agouti) to metabolic syndrome: a possible involvement of the cocaine- and amphetamine-regulated transcript system

    Article • Genes & Nutrition, November 2010, Springer Science + Business Media

    Carlo Cifani

  93. Role of Dorsal Medial Prefrontal Cortex Dopamine D1-Family Receptors in Relapse to High-Fat Food Seeking Induced by the Anxiogenic Drug Yohimbine

    Article • Neuropsychopharmacology, October 2010, Springer Science + Business Media

    Carlo Cifani

  94. UFP-112 a Potent and Long-Lasting Agonist Selective for the Nociceptin/Orphanin FQ Receptor

    Article • CNS Neuroscience & Therapeutics, May 2010, Wiley

    Carlo Cifani

  95. Further studies on the pharmacological profile of the neuropeptide S receptor antagonist SHA 68

    Article • Peptides, May 2010, Elsevier

    Carlo Cifani

  96. The paraventricular nucleus of the hypothalamus is a neuroanatomical substrate for the inhibition of palatable food intake by neuropeptide S

    Article • European Journal of Neuroscience, October 2009, Wiley

    Carlo Cifani

  97. Pre-exposure to environmental cues predictive of food availability elicits hypothalamic-pituitary-adrenal axis activation and increases operant responding for food in female rats

    Article • Addiction Biology, October 2009, Wiley

    Carlo Cifani

  98. Chronic treatment with the selective NOP receptor antagonist [Nphe1,Arg14,Lys15]N/OFQ-NH2 (UFP-101) reverses the behavioural and biochemical effects of unpredictable chronic mild stress in rats

    Article • Psychopharmacology, August 2009, Springer Science + Business Media

    Dr Silvia Alboni, Carlo Cifani

  99. Possible common central pathway for resistin and insulin in regulating food intake

    Article • Acta Physiologica, August 2009, Wiley

    Carlo Cifani

  100. Nociceptin/orphanin FQ-induced food intake and cocaine amphetamine regulated transcript gene expression in strains derived from rats prone (WOKW) and resistant (Dark Agouti) to metabolic syndrome

    Article • Peptides, April 2009, Elsevier

    Carlo Cifani

  101. A preclinical model of binge eating elicited by yo-yo dieting and stressful exposure to food: effect of sibutramine, fluoxetine, topiramate, and midazolam

    Article • Psychopharmacology, January 2009, Springer Science + Business Media

    Carlo Cifani

  102. Functional antagonism between nociceptin/orphanin FQ (N/OFQ) and corticotropin-releasing factor (CRF) in the rat brain: evidence for involvement of the bed nucleus of the stria terminalis

    Article • Psychopharmacology, November 2007, Springer Science + Business Media

    Carlo Cifani

  103. Involvement of cocaine–amphetamine regulated transcript in the differential feeding responses to nociceptin/orphanin FQ in dark agouti and Wistar Ottawa Karlsburg W rats

    Article • Peptides, October 2007, Elsevier

    Carlo Cifani

  104. Oxidative damage in rat erythrocyte membranes following ethanol intake: Effect of ethyl pyruvate

    Article • Chemico-Biological Interactions, August 2007, Elsevier

    Carlo Cifani

  105. Protective effect of ethyl pyruvate on msP rat leukocytes damaged by alcohol intake

    Article • Journal of Applied Toxicology, January 2007, Wiley

    Carlo Cifani

  106. Chronic intracerebroventricular infusion of nociceptin/orphanin FQ increases food and ethanol intake in alcohol-preferring rats

    Article • Peptides, November 2006, Elsevier

    Carlo Cifani

  107. Anxiolytic-like effects of nociceptin/orphanin FQ in the elevated plus maze and in the conditioned defensive burying test in rats

    Article • Peptides, September 2006, Elsevier

    Carlo Cifani

  108. Effect of the cannabinoid CB1 receptor antagonist SR-141716A on ethanol self-administration and ethanol-seeking behaviour in rats

    Article • Psychopharmacology, November 2005, Springer Science + Business Media

    Professor luigia trabace, Carlo Cifani