All Stories

  1. The complexities and versatility of the RAS-to-ERK signalling system in normal and cancer cells

    Article • Seminars in Cell and Developmental Biology, October 2016, Elsevier

    Professor Boris N. Kholodenko

  2. Rac1 and RhoA: Networks, loops and bistability

    Article • Small GTPases, August 2016, Taylor & Francis

    Professor Boris N. Kholodenko

  3. Three-factor models versus time series models: quantifying time-dependencies of interactions between stimuli in cell biology and psychobiology for short longitudinal data

    Article • Mathematical Medicine and Biology A Journal of the IMA, April 2016, Oxford University Press (OUP)

    Professor Boris N. Kholodenko

  4. Feedback regulation in cell signalling: Lessons for cancer therapeutics

    Article • Seminars in Cell and Developmental Biology, February 2016, Elsevier

    Professor Boris N. Kholodenko

  5. Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches

    Article • Cell Systems, January 2016, Elsevier

    Professor Boris N. Kholodenko

  6. Phosphorylation of RAF Kinase Dimers Drives Conformational Changes that Facilitate Transactivation

    Article • Angewandte Chemie, December 2015, Wiley

    Professor Boris N. Kholodenko

  7. Phosphorylation of RAF Kinase Dimers Drives Conformational Changes that Facilitate Transactivation

    Article • Angewandte Chemie International Edition, December 2015, Wiley

    Professor Boris N. Kholodenko, Pablo G. Jambrina

  8. Abstract CN05-03: Personalized cancer diagnostics and therapeutics based on the computational modeling of signal transduction networks

    Article • Molecular Cancer Therapeutics, December 2015, American Association for Cancer Research (AACR)

    Professor Boris N. Kholodenko

  9. MST2-RASSF protein–protein interactions through SARAH domains

    Article • Briefings in Bioinformatics, October 2015, Oxford University Press (OUP)

    Professor Boris N. Kholodenko, Dr Goar Sanchez

  10. Drug Resistance Resulting from Kinase Dimerization Is Rationalized by Thermodynamic Factors Describing Allosteric Inhibitor Effects

    Article • Cell Reports, September 2015, Elsevier

    Professor Boris N. Kholodenko

  11. The dynamic control of signal transduction networks in cancer cells

    Article • Nature Reviews Drug Discovery, August 2015, Nature

    Professor Boris N. Kholodenko

  12. DYVIPAC: an integrated analysis and visualisation framework to probe multi-dimensional biological networks

    Article • Scientific Reports, July 2015, Nature

    Professor Boris N. Kholodenko

  13. G Protein–Coupled Receptor Signaling Networks from a Systems Perspective

    Article • Molecular Pharmacology, July 2015, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Boris N. Kholodenko

  14. Mitogen-Inducible Gene-6 Mediates Feedback Inhibition from Mutated BRAF towards the Epidermal Growth Factor Receptor and Thereby Limits Malignant Transformation

    Article • PLoS ONE, June 2015, PLOS

    Professor Boris N. Kholodenko

  15. Silence on the relevant literature and errors in implementation

    Article • Nature Biotechnology, April 2015, Nature

    Professor Boris N. Kholodenko

  16. Signalling mechanisms regulating phenotypic changes in breast cancer cells

    Article • Bioscience Reports, March 2015, Portland Press Ltd.

    Professor Boris N. Kholodenko

  17. Network-based identification of feedback modules that control RhoA activity and cell migration

    Article • Journal of Molecular Cell Biology, March 2015, Oxford University Press (OUP)

    Professor Boris N. Kholodenko

  18. Advances in dynamic modeling of colorectal cancer signaling-network regions, a path toward targeted therapies

    Article • Oncotarget, March 2015, Impact Journals, LLC

    Professor Boris N. Kholodenko

  19. Species differential regulation of COX2 can be described by an NFκB-dependent logic AND gate

    Article • Cellular and Molecular Life Sciences, February 2015, Springer Science + Business Media

    Professor Boris N. Kholodenko

  20. Competing to coordinate cell fate decisions: the MST2-Raf-1 signaling device

    Article • Cell Cycle, January 2015, Taylor & Francis

    Professor Boris N. Kholodenko, Dr David Matallanas

  21. A dynamic model of the hypoxia-inducible factor 1a (HIF-1a) network

    Article • Journal of Cell Science, January 2015, The Company of Biologists

    Professor Boris N. Kholodenko

  22. Feedforward regulation of mRNA stability by prolonged extracellular signal-regulated kinase activity

    Article • FEBS Journal, January 2015, Wiley

    Professor Boris N. Kholodenko

  23. Protein–protein interactions generate hidden feedback and feed-forward loops to trigger bistable switches, oscillations and biphasic dose–responses

    Article • Molecular BioSystems, January 2015, Royal Society of Chemistry

    Professor Boris N. Kholodenko

  24. Ubiquitin chain specific auto-ubiquitination triggers sustained oscillation, bistable switches and excitable firing

    Article • IET Systems Biology, December 2014, the Institution of Engineering and Technology (the IET)

    Professor Boris N. Kholodenko

  25. HER2-HER3 dimer quantification by FLIM-FRET predicts breast cancer metastatic relapse independently of HER2 IHC status

    Article • Oncotarget, November 2014, Impact Journals, LLC

    Professor Boris N. Kholodenko

  26. The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility

    Article • Science Signaling, August 2014, American Association for the Advancement of Science

    Professor Boris N. Kholodenko

  27. Nonlinear signalling networks and cell-to-cell variability transform external signals into broadly distributed or bimodal responses

    Article • Journal of The Royal Society Interface, June 2014, Royal Society Publishing

    Dr Maciej Dobrzynski, Professor Boris N. Kholodenko

  28. Protein interaction switches coordinate Raf-1 and MST2/Hippo signalling

    Article • Nature Cell Biology, June 2014, Springer Science + Business Media

    Dr David Matallanas, Professor Boris N. Kholodenko

  29. The APC Network Regulates the Removal of Mutated Cells from Colonic Crypts

    Article • Cell Reports, April 2014, Elsevier

    Professor Boris N. Kholodenko

  30. Navigating the Multilayered Organization of Eukaryotic Signaling: A New Trend in Data Integration

    Article • PLoS Computational Biology, February 2014, PLOS

    Professor Boris N. Kholodenko

  31. Evaluating Strategies to Normalise Biological Replicates of Western Blot Data

    Article • PLoS ONE, January 2014, PLOS

    Marc Birtwistle, Professor Boris N. Kholodenko

  32. Polyubiquitin chain assembly and organization determine the dynamics of protein activation and degradation

    Article • Frontiers in Physiology, January 2014, Frontiers

    Dr Maciej Dobrzynski, Professor Boris N. Kholodenko

  33. Systems biology-embedded target validation: improving efficacy in drug discovery

    Article • WIREs Systems Biology and Medicine, November 2013, Wiley

    Professor Boris N. Kholodenko

  34. Systems medicine: opportunities and challenges for systems biology approaches

    Article • FEBS Journal, October 2013, Wiley

    Professor Boris N. Kholodenko

  35. Pseudophosphatase STYX modulates cell-fate decisions and cell migration by spatiotemporal regulation of ERK1/2

    Article • Proceedings of the National Academy of Sciences, July 2013, Proceedings of the National Academy of Sciences

    Professor Boris N. Kholodenko

  36. A dynamic model of the hypoxia-inducible factor 1  (HIF-1 ) network

    Article • Journal of Cell Science, February 2013, The Company of Biologists

    Professor Boris N. Kholodenko

  37. Control of the G-protein cascade dynamics by GDP dissociation inhibitors

    Article • Molecular BioSystems, January 2013, Royal Society of Chemistry

    Professor Boris N. Kholodenko

  38. It takes two to tango – signalling by dimeric Raf kinases

    Article • Molecular BioSystems, January 2013, Royal Society of Chemistry

    Professor Boris N. Kholodenko

  39. When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling

    Article • Cell Communication and Signaling, January 2013, Springer Science + Business Media

    Professor Boris N. Kholodenko

  40. Integrating Bayesian variable selection with Modular Response Analysis to infer biochemical network topology

    Article • BMC Systems Biology, January 2013, Springer Science + Business Media

    Professor Boris N. Kholodenko

  41. Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise

    Article • BMC Systems Biology, August 2012, Springer Science + Business Media

    Marc Birtwistle, Dr Maciej Dobrzynski, Professor Boris N. Kholodenko

  42. Catching transcriptional regulation by thermostatistical modeling

    Article • Physical Biology, August 2012, Institute of Physics Publishing

    Professor Boris N. Kholodenko

  43. Computational Approaches for Analyzing Information Flow in Biological Networks

    Article • Science Signaling, April 2012, American Association for the Advancement of Science

    Professor Boris N. Kholodenko

  44. Versatility of Cooperative Transcriptional Activation: A Thermodynamical Modeling Analysis for Greater-Than-Additive and Less-Than-Additive Effects

    Article • PLoS ONE, April 2012, PLOS

    Professor Boris N. Kholodenko

  45. Signalling by protein phosphatases and drug development: a systems-centred view

    Article • FEBS Journal, March 2012, Wiley

    Dr David Matallanas, Professor Boris N. Kholodenko

  46. Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance

    Article • Biochemical Society Transactions, February 2012, Portland Press Ltd.

    Professor Boris N. Kholodenko

  47. Mammalian protein expression noise: scaling principles and the implications for knockdown experiments

    Article • Molecular BioSystems, January 2012, Royal Society of Chemistry

    Marc Birtwistle, Dr Maciej Dobrzynski, Professor Boris N. Kholodenko

  48. Bimodal Protein Distributions in Heterogeneous Oscillating Systems

    Article • January 2012, Springer Science + Business Media

    Dr Maciej Dobrzynski, Professor Boris N. Kholodenko

  49. The topology design principles that determine the spatiotemporal dynamics of G-protein cascades

    Article • Molecular BioSystems, January 2012, Royal Society of Chemistry

    Professor Boris N. Kholodenko

  50. Crosstalk and Signaling Switches in Mitogen-Activated Protein Kinase Cascades

    Article • Frontiers in Physiology, January 2012, Frontiers

    Professor Boris N. Kholodenko

  51. Understanding Cell Fate Decisions by Identifying Crucial System Dynamics

    Article • January 2012, Springer Science + Business Media

    Professor Boris N. Kholodenko

  52. Switches, Excitable Responses and Oscillations in the Ring1B/Bmi1 Ubiquitination System

    Article • PLoS Computational Biology, December 2011, PLOS

    Professor Boris N. Kholodenko

  53. An Integrated Bayesian Framework for Identifying Phosphorylation Networks in Stimulated Cells

    Article • November 2011, Springer Science + Business Media

    Professor Boris N. Kholodenko

  54. Prolactin-stimulated activation of ERK1/2 mitogen-activated protein kinases is controlled by PI3-kinase/Rac/PAK signaling pathway in breast cancer cells

    Article • Cellular Signalling, November 2011, Elsevier

    Professor Boris N. Kholodenko

  55. Signalling over a distance: gradient patterns and phosphorylation waves within single cells

    Article • Biochemical Society Transactions, October 2010, Portland Press Ltd.

    Professor Boris N. Kholodenko

  56. PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells

    Article • Cellular Signalling, September 2010, Elsevier

    Professor Boris N. Kholodenko

  57. Formation of Intracellular Concentration Landscapes by Multisite Protein Modification

    Article • Biophysical Journal, July 2010, Elsevier

    Professor Boris N. Kholodenko

  58. Signalling ballet in space and time

    Article • Nature Reviews Molecular Cell Biology, June 2010, Springer Science + Business Media

    Professor Boris N. Kholodenko

  59. Ligand-Specific c-Fos Expression Emerges from the Spatiotemporal Control of ErbB Network Dynamics

    Article • Cell, May 2010, Elsevier

    Marc Birtwistle, Professor Boris N. Kholodenko

  60. Spatially distributed cell signalling

    Article • FEBS Letters, October 2009, Wiley

    Professor Boris N. Kholodenko

  61. Toggle switches, pulses and oscillations are intrinsic properties of the Src activation/deactivation cycle

    Article • FEBS Journal, August 2009, Wiley

    Professor Boris N. Kholodenko

  62. Endocytosis and signalling: A meeting with mathematics

    Article • Molecular Oncology, June 2009, Wiley

    Marc Birtwistle, Professor Boris N. Kholodenko

  63. Four‐dimensional dynamics of MAPK information‐processing systems

    Article • WIREs Systems Biology and Medicine, May 2009, Wiley

    Marc Birtwistle, Professor Boris N. Kholodenko

  64. Systems-level interactions between insulin–EGF networks amplify mitogenic signaling

    Article • Molecular Systems Biology, April 2009, EMBO

    Professor Boris N. Kholodenko

  65. Positional Information Generated by Spatially Distributed Signaling Cascades

    Article • PLoS Computational Biology, March 2009, PLOS

    Professor Boris N. Kholodenko

  66. Molecular Dynamics Simulations Reveal that Tyr-317 Phosphorylation Reduces Shc Binding Affinity for Phosphotyrosyl Residues of Epidermal Growth Factor Receptor

    Article • Biophysical Journal, March 2009, Elsevier

    Professor Boris N. Kholodenko

  67. Domain-oriented reduction of rule-based network models

    Article • IET Systems Biology, September 2008, the Institution of Engineering and Technology (the IET)

    Professor Boris N. Kholodenko

  68. Giving Space to Cell Signaling

    Article • Cell, May 2008, Elsevier

    Professor Boris N. Kholodenko

  69. Signaling cascades as cellular devices for spatial computations

    Article • Journal of Mathematical Biology, February 2008, Springer Science + Business Media

    Professor Boris N. Kholodenko

  70. Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses

    Article • Molecular Systems Biology, November 2007, EMBO

    Marc Birtwistle, Professor Boris N. Kholodenko

  71. Multistrip Western blotting to increase quantitative data output

    Article • Electrophoresis, September 2007, Wiley

    Professor Boris N. Kholodenko

  72. Untangling the signalling wires

    Article • Nature Cell Biology, March 2007, Springer Science + Business Media

    Professor Boris N. Kholodenko

  73. Oscillatory dynamics arising from competitive inhibition and multisite phosphorylation

    Article • Journal of Theoretical Biology, January 2007, Elsevier

    Professor Boris N. Kholodenko

  74. Long-range signaling by phosphoprotein waves arising from bistability in protein kinase cascades

    Article • Molecular Systems Biology, November 2006, EMBO

    Professor Boris N. Kholodenko

  75. Bistability from double phosphorylation in signal transduction

    Article • FEBS Journal, August 2006, Wiley

    Professor Boris N. Kholodenko

  76. Effects of sequestration on signal transduction cascades

    Article • FEBS Journal, March 2006, Wiley

    Professor Boris N. Kholodenko

  77. Cell-signalling dynamics in time and space

    Article • Nature Reviews Molecular Cell Biology, February 2006, Springer Science + Business Media

    Professor Boris N. Kholodenko

  78. Trading the micro-world of combinatorial complexity for the macro-world of protein interaction domains

    Article • Biosystems, February 2006, Elsevier

    Professor Boris N. Kholodenko

  79. Theoretical model of the full-length human p52 Shc adaptor protein obtained by homology modeling and 2 ns Molecular Dynamics simulations

    Article • September 2005, Protein Data Bank, Rutgers University

    Professor Boris N. Kholodenko

  80. Signaling through Receptors and Scaffolds: Independent Interactions Reduce Combinatorial Complexity

    Article • Biophysical Journal, August 2005, Elsevier

    Professor Boris N. Kholodenko

  81. Inference of signaling and gene regulatory networks by steady-state perturbation experiments: structure and accuracy

    Article • Journal of Theoretical Biology, February 2005, Elsevier

    Professor Boris N. Kholodenko

  82. Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades

    Article • The Journal of Cell Biology, January 2004, Rockefeller University Press

    Professor Boris N. Kholodenko

  83. Control of spatially heterogeneous and time-varying cellular reaction networks: a new summation law

    Article • Journal of Theoretical Biology, December 2003, Elsevier

    Professor Boris N. Kholodenko

  84. Four-dimensional organization of protein kinase signaling cascades: the roles of diffusion, endocytosis and molecular motors

    Article • Journal of Experimental Biology, June 2003, The Company of Biologists

    Professor Boris N. Kholodenko

  85. Modular Response Analysis of Cellular Regulatory Networks

    Article • Journal of Theoretical Biology, October 2002, Elsevier

    Professor Boris N. Kholodenko

  86. MAP kinase cascade signaling and endocytic trafficking: a marriage of convenience?

    Article • Trends in Cell Biology, April 2002, Elsevier

    Professor Boris N. Kholodenko

  87. Control Analysis for Autonomously Oscillating Biochemical Networks

    Article • Biophysical Journal, January 2002, Elsevier

    Professor Boris N. Kholodenko

  88. Temperature Dependence of the Epidermal Growth Factor Receptor Signaling Network Can Be Accounted for by a Kinetic Model †

    Article • Biochemistry, January 2002, American Chemical Society (ACS)

    Professor Boris N. Kholodenko

  89. Occurrence of paradoxical or sustained control by an enzyme when overexpressed: necessary conditions and experimental evidence with regard to hepatic glucokinase

    Article • Biochemical Journal, May 2001, Portland Press Ltd.

    Professor Boris N. Kholodenko

  90. Diffusion control of protein phosphorylation in signal transduction pathways

    Article • Biochemical Journal, September 2000, Portland Press Ltd.

    Professor Boris N. Kholodenko

  91. Diffusion control of protein phosphorylation in signal transduction pathways

    Article • Biochemical Journal, September 2000, Portland Press Ltd.

    Professor Boris N. Kholodenko

  92. Kinetics and control of oxidative phosphorylation in rat liver mitochondria after chronic ethanol feeding

    Article • Biochemical Journal, July 2000, Portland Press Ltd.

    Professor Boris N. Kholodenko

  93. Kinetics and control of oxidative phosphorylation in rat liver mitochondria after chronic ethanol feeding

    Article • Biochemical Journal, July 2000, Portland Press Ltd.

    Professor Boris N. Kholodenko

  94. Why cytoplasmic signalling proteins should be recruited to cell membranes

    Article • Trends in Cell Biology, May 2000, Elsevier

    Professor Boris N. Kholodenko

  95. Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase cascades

    Article • European Journal of Biochemistry, March 2000, Wiley

    Professor Boris N. Kholodenko

  96. Cellular information transfer regarded from a stoichiometry and control analysis perspective

    Article • Biosystems, February 2000, Elsevier

    Professor Boris N. Kholodenko

  97. Engineering a Living Cell to Desired Metabolite Concentrations and Fluxes: Pathways with Multifunctional Enzymes

    Article • Metabolic Engineering, January 2000, Elsevier

    Professor Boris N. Kholodenko

  98. Metabolic Control From The Back Benches: Biochemistry Towards Biocomplexity

    Article • January 2000, Springer Science + Business Media

    Professor Boris N. Kholodenko

  99. Control Analysis of Stationary Forced Oscillations

    Article • The Journal of Physical Chemistry, December 1999, American Chemical Society (ACS)

    Professor Boris N. Kholodenko

  100. Spatial gradients of cellular phospho-proteins

    Article • FEBS Letters, September 1999, Wiley

    Professor Boris N. Kholodenko

  101. Live Control of the Living Cell

    Article • Biochemical Society Transactions, February 1999, Portland Press Ltd.

    Professor Boris N. Kholodenko

  102. The Intracellular Signaling Network as a Target for Ethanol

    Article • Alcoholism Clinical and Experimental Research, August 1998, Wiley

    Professor Boris N. Kholodenko

  103. Metabolic design: How to engineer a living cell to desired metabolite concentrations and fluxes

    Article • Biotechnology and Bioengineering, July 1998, Wiley

    Professor Boris N. Kholodenko

  104. Control analysis of metabolic systems involving quasi-equilibrium reactions

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, March 1998, Elsevier

    Professor Boris N. Kholodenko

  105. Thermodynamics of complexity. The live cell

    Article • Thermochimica Acta, January 1998, Elsevier

    Professor Boris N. Kholodenko

  106. Subtleties in control by metabolic channelling and enzyme organization

    Article • January 1998, Springer Science + Business Media

    Professor Boris N. Kholodenko

  107. A model of O·2 -generation in the complex III of the electron transport chain

    Article • January 1998, Springer Science + Business Media

    Professor Boris N. Kholodenko

  108. Why do protein kinase cascades have more than one level?

    Article • Trends in Biochemical Sciences, August 1997, Elsevier

    Professor Boris N. Kholodenko

  109. Control Analysis of Periodic Phenomena in Biological Systems

    Article • The Journal of Physical Chemistry, March 1997, American Chemical Society (ACS)

    Professor Boris N. Kholodenko

  110. Ca 2+ stimulates both the respiratory and phosphorylation subsystems in rat heart mitochondria

    Article • Biochemical Journal, November 1996, Portland Press Ltd.

    Professor Boris N. Kholodenko

  111. Control analysis of glycolytic oscillations

    Article • Biophysical Chemistry, November 1996, Elsevier

    Professor Boris N. Kholodenko

  112. Molecular Control Analysis: Control within Proteins and Molecular Processes

    Article • Journal of Theoretical Biology, October 1996, Elsevier

    Professor Boris N. Kholodenko

  113. Strong control on the transit time in metabolic channelling

    Article • FEBS Letters, July 1996, Wiley

    Professor Boris N. Kholodenko

  114. Paradoxical control properties of enzymes within pathways: can activation cause an enzyme to have increased control?

    Article • Biochemical Journal, March 1996, Portland Press Ltd.

    Professor Boris N. Kholodenko

  115. Effect of channelling on the concentration of bulk-phase intermediates as cytosolic proteins become more concentrated

    Article • Biochemical Journal, February 1996, Portland Press Ltd.

    Professor Boris N. Kholodenko

  116. Steady-State Characterization of Systems with Moiety-Conservations Made Easy: Matrix Equations of Metabolic Control Analysis and Biochemical System Theory

    Article • Journal of Theoretical Biology, January 1996, Elsevier

    Professor Boris N. Kholodenko

  117. Direct Transfer of Control and Multidrug Resistance

    Article • January 1996, Springer Science + Business Media

    Professor Boris N. Kholodenko

  118. Calcium Indirectly Increases the Control Exerted by the Adenine Nucleotide Translocator over 2-Oxoglutarate Oxidation in Rat Heart Mitochondria

    Article • Archives of Biochemistry and Biophysics, December 1995, Elsevier

    Professor Boris N. Kholodenko

  119. Defining control coefficients in non-ideal metabolic pathways

    Article • Biophysical Chemistry, November 1995, Elsevier

    Professor Boris N. Kholodenko

  120. Elusive control

    Article • Journal of Bioenergetics and Biomembranes, October 1995, Springer Science + Business Media

    Professor Boris N. Kholodenko

  121. Composite control of cell function: metabolic pathways behaving as single control units

    Article • FEBS Letters, July 1995, Wiley

    Professor Boris N. Kholodenko

  122. Control theory of group transfer pathways

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, April 1995, Elsevier

    Professor Boris N. Kholodenko

  123. How to reveal various aspects of regulation in group-transfer pathways

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, April 1995, Elsevier

    Professor Boris N. Kholodenko

  124. CONTROL THEORY OF CELL METABOLISM: TOWARDS MORE REALISTIC “NON-IDEAL” SYSTEMS

    Article • Journal of Biological System, March 1995, World Scientific Pub Co Pte Lt

    Professor Boris N. Kholodenko

  125. DYNAMIC ASPECTS OF CASCADE-TYPE METABOLIC REGULATION

    Article • Journal of Biological System, March 1995, World Scientific Pub Co Pte Lt

    Professor Boris N. Kholodenko

  126. Control theory of metabolic channelling

    Article • Molecular and Cellular Biochemistry, February 1995, Springer Science + Business Media

    Professor Boris N. Kholodenko

  127. Control theory of one enzyme

    Article • Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, October 1994, Elsevier

    Professor Boris N. Kholodenko

  128. Control by Enzymes, Coenzymes and Conserved Moieties. A Generalisation of the Connectivity Theorem of Metabolic Control Analysis

    Article • European Journal of Biochemistry, October 1994, Wiley

    Professor Boris N. Kholodenko

  129. Rate limitation within a single enzyme is directly related to enzyme intermediate levels

    Article • FEBS Letters, July 1994, Wiley

    Professor Boris N. Kholodenko

  130. Getting to the inside of cells using metabolic control analysis

    Article • Biophysical Chemistry, June 1994, Elsevier

    Professor Boris N. Kholodenko

  131. Control theory of metabolic channelling

    Article • Molecular and Cellular Biochemistry, April 1994, Springer Science + Business Media

    Professor Boris N. Kholodenko

  132. Control theory of metabolic channelling

    Article • January 1994, Springer Science + Business Media

    Professor Boris N. Kholodenko

  133. Dramatic changes in control properties that accompany channelling and metabolite sequestration

    Article • FEBS Letters, December 1993, Wiley

    Professor Boris N. Kholodenko

  134. Kinetic models of coupling between H+ and Na+-translocation and ATP synthesis/hydrolysis by F0F1-ATPases: Can a cell utilize both $$\Delta \bar \mu _{H^ + } $$ and $$\Delta \bar \mu _{Na^ + } $$ for ATP synthesis underin vivo conditions using the same ...

    Article • Journal of Bioenergetics and Biomembranes, June 1993, Springer Science + Business Media

    Professor Boris N. Kholodenko

  135. The function of ATP/ADP translocator in the regulation of mitochondrial respiration during development of heart ischemic injury

    Article • Biochimica et Biophysica Acta (BBA) - Bioenergetics, April 1993, Elsevier

    Dr Vilmante Borutaite, Professor Boris N. Kholodenko

  136. Metabolic channelling and control of the flux

    Article • FEBS Letters, March 1993, Wiley

    Professor Boris N. Kholodenko

  137. ‘Channelled’ pathways can be more sensitive to specific regulatory signals

    Article • FEBS Letters, March 1993, Wiley

    Professor Boris N. Kholodenko

  138. The sum of the control coefficients of all enzymes on the flux through a group-transfer pathway can be as high as two

    Article • European Journal of Biochemistry, March 1993, Wiley

    Professor Boris N. Kholodenko

  139. Sum of the Flux Control Coefficients: What is it Equal to in Different Systems?

    Article • January 1993, Springer Science + Business Media

    Professor Boris N. Kholodenko

  140. Multiplicity of Control

    Article • January 1993, Springer Science + Business Media

    Professor Boris N. Kholodenko

  141. Control of the metabolic flux in a system with high enzyme concentrations and moiety-conserved cycles. The sum of the flux control coefficients can drop significantly below unity

    Article • European Journal of Biochemistry, November 1992, Wiley

    Professor Boris N. Kholodenko

  142. Control of mitochondrial oxidative phosphorylation

    Article • Journal of Theoretical Biology, March 1984, Elsevier

    Professor Boris N. Kholodenko

  143. The Regulation of Glycolysis in Human Erythrocytes. The Dependence of the Glycolytic Flux on the ATP Concentration

    Article • European Journal of Biochemistry, April 1981, Wiley

    Professor Boris N. Kholodenko

  144. Employing Systems Biology to Quantify Receptor Tyrosine Kinase Signaling in Time and Space

    Article • Springer Science + Business Media

    Professor Boris N. Kholodenko

  145. Mechanisms Generating Ultrasensitivity, Bistability, and Oscillations in Signal Transduction

    Article • Springer Science + Business Media

    Professor Boris N. Kholodenko

  146. Nonlinear control and self-organization

    Article • De Gruyter

    Professor Boris N. Kholodenko

  147. Mechanistic and modular approaches to modeling and inference of cellular regulatory networks

    Article • Springer Science + Business Media

    Professor Boris N. Kholodenko