All Stories

  1. Tailoring FXR Modulators for Intestinal Specificity: Recent Progress and Insights

    Article • Molecules, April 2024, MDPI AG

    Professor Bahaa Elgendy

  2. Exploring 2,5-Diketopiperazines as Promising Agents in Cancer Treatment

    Article • Current Pharmaceutical Design, March 2024, Bentham Science Publishers

    Shaimaa Goher, Professor Bahaa Elgendy

  3. Estrogen-Related Receptor Agonism Reverses Mitochondrial Dysfunction and Inflammation in the Aging Kidney

    Article • American Journal Of Pathology, December 2023, Elsevier

    Professor Bahaa Elgendy

  4. Synthesis of 3-Aminoquinazolinones via a SnCl2-Mediated ANRORC-like Reductive Rearrangement of 1,3,4-Oxadiazoles

    Article • The Journal of Organic Chemistry, November 2023, American Chemical Society (ACS)

    Professor Bahaa Elgendy

  5. A Synthetic ERR Agonist Alleviates Metabolic Syndrome

    Article • Journal of Pharmacology and Experimental Therapeutics, September 2023, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Bahaa Elgendy

  6. International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily—Update 2023

    Article • Pharmacological Reviews, August 2023, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Bahaa Elgendy

  7. Identification of new 4-(6-oxopyridazin-1-yl)benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: synthesis, biological evaluations and modelling insights

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, April 2023, Taylor & Francis

    Wagdy Eldehna, Professor Bahaa Elgendy

  8. REV-ERB activation as a novel pharmacological approach for treating inflammatory pain

    Article • Frontiers in Pharmacology, April 2023, Frontiers

    Professor Bahaa Elgendy

  9. Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity

    Article • ACS Chemical Biology, March 2023, American Chemical Society (ACS)

    Professor Bahaa Elgendy

  10. 4-(5-Amino-pyrazol-1-yl)benzenesulfonamide derivatives as novel multi-target anti-inflammatory agents endowed with inhibitory activity against COX-2, 5-LOX and carbonic anhydrase: Design, synthesis, and biological assessments

    Article • European Journal of Medicinal Chemistry, March 2023, Elsevier

    Wagdy Eldehna, Professor Bahaa Elgendy

  11. Facile Synthesis and Dft - Tddft Studies of Charge Transfer Complexes in Vitro [Hbt] and [Fbt] 4,5,6,7 Tetrahydrobenzo [B]Thiophene-3-Carbonitrile with Nitrobenzene as Π Acceptors

    Article • January 2023, Elsevier

    Professor Bahaa Elgendy

  12. Structural basis of synthetic agonist activation of the nuclear receptor REV-ERB

    Article • Nature Communications, November 2022, Springer Science + Business Media

    Professor Bahaa Elgendy

  13. A Synthetic ERRα Agonist Induces an Acute Aerobic Exercise Response and Enhances Exercise Capacity

    Article • October 2022, Cold Spring Harbor Laboratory Press

    Professor Bahaa Elgendy

  14. Metal coordinating inhibitors of Rift Valley fever virus replication

    Article • PLoS ONE, September 2022, PLOS

    Professor Bahaa Elgendy

  15. Ligand-based design, synthesis, computational insights, andin vitrostudies of novelN-(5-Nitrothiazol-2-yl)-carboxamido derivatives as potent inhibitors of SARS-CoV-2 main protease

    Article • Journal of Enzyme Inhibition and Medicinal Chemistry, July 2022, Taylor & Francis

    Professor Bahaa Elgendy

  16. Antihyperlipidemic Activity of Gut-Restricted LXR Inverse Agonists

    Article • ACS Chemical Biology, April 2022, American Chemical Society (ACS)

    Professor Bahaa Elgendy

  17. Metal Coordinating Inhibitors of Rift Valley Fever virus Replication

    Article • March 2022, Cold Spring Harbor Laboratory Press

    Professor Bahaa Elgendy

  18. Emerging Role of Nuclear Receptors for the Treatment of NAFLD and NASH

    Article • Metabolites, March 2022, MDPI AG

    Professor Bahaa Elgendy

  19. Identification of Novel Mitochondrial Pyruvate Carrier Inhibitors by Homology Modeling and Pharmacophore-Based Virtual Screening

    Article • Biomedicines, February 2022, MDPI AG

    Professor Bahaa Elgendy

  20. Structure-based design and synthesis of conformationally constrained derivatives of methyl-piperidinopyrazole (MPP) with estrogen receptor (ER) antagonist activity

    Article • Bioorganic Chemistry, February 2022, Elsevier

    Dr. Shaymaa Emam Kassab, Professor Bahaa Elgendy

  21. Mitochondrial pyruvate carrier inhibitors improve metabolic parameters in diet-induced obese mice

    Article • Journal of Biological Chemistry, February 2022, Elsevier

    Professor Bahaa Elgendy

  22. Synthesis and structure activity relationship of the first class of LXR inverse agonists

    Article • Bioorganic Chemistry, February 2022, Elsevier

    Professor Bahaa Elgendy

  23. Design, Synthesis and Antitumor Activity of Novel Dispiro[oxindole-cyclohexanone]- pyrrolidines

    Article • Current Pharmaceutical Design, January 2022, Bentham Science Publishers

    Professor Bahaa Elgendy

  24. Recent Advances in the Medicinal Chemistry of Farnesoid X Receptor

    Article • Journal of Medicinal Chemistry, December 2021, American Chemical Society (ACS)

    Professor Bahaa Elgendy

  25. Potent antiplasmodial alkaloids from the rhizobacterium Pantoea agglomerans as hemozoin modulators

    Article • Bioorganic Chemistry, October 2021, Elsevier

    Professor Bahaa Elgendy

  26. Distinct REV-ERBα Conformational State Predicted by GaMD Simulations Leads to the Structure-Based Discovery of Novel REV-ERBα Antagonist

    Article • May 2021, Cold Spring Harbor Laboratory Press

    Professor Bahaa Elgendy

  27. Enhancement for the fluorescent properties of new synthesized GFPs chromophore

    Article • Egyptian Journal of Chemistry, April 2021, Egypts Presidential Specialized Council for Education and Scientific Research

    Professor Bahaa Elgendy

  28. Novel synthesis of benzotriazolyl alkyl esters: an unprecedented CH2 insertion

    Article • RSC Advances, January 2021, Royal Society of Chemistry

    Professor Bahaa Elgendy

  29. Design and synthesis of novel pyrazolo[3,4-d]pyrimidin-4-one bearing quinoline scaffold as potent dual PDE5 inhibitors and apoptotic inducers for cancer therapy

    Article • Bioorganic Chemistry, December 2020, Elsevier

    Prof. Gamal Zayed, Professor Bahaa Elgendy

  30. REV-ERB agonism improves liver pathology in a mouse model of NASH

    Article • PLoS ONE, October 2020, PLOS

    Professor Bahaa Elgendy

  31. Synthesis, assessment and corrosion protection investigations of some novel peptidomimetic cationic surfactants: Empirical and theoretical insights

    Article • Journal of Molecular Liquids, October 2020, Elsevier

    Professor Bahaa Elgendy

  32. Modulation of estrogen-related receptors subtype selectivity: Conversion of an ERRβ/γ selective agonist to ERRα/β/γ pan agonists

    Article • Bioorganic Chemistry, September 2020, Elsevier

    Professor Bahaa Elgendy

  33. Expanding the anticancer potential of 1,2,3-triazoles via simultaneously targeting Cyclooxygenase-2, 15-lipoxygenase and tumor-associated carbonic anhydrases

    Article • European Journal of Medicinal Chemistry, August 2020, Elsevier

    Professor Bahaa Elgendy

  34. Design, synthesis, and pharmacological evaluation of novel and selective COX-2 inhibitors based on bumetanide scaffold

    Article • Bioorganic Chemistry, July 2020, Elsevier

    Professor Bahaa Elgendy

  35. REV-ERB Agonism Improves Liver Pathology in a Mouse Model of NASH

    Article • June 2020, Cold Spring Harbor Laboratory Press

    Professor Bahaa Elgendy

  36. Catalyst-and organic solvent-free synthesis, structural, and theoretical studies of 1-arylidenamino-2,4-disubstituted-2-imidazoline-5-ones

    Article • Results in Chemistry, January 2020, Elsevier

    Professor Bahaa Elgendy

  37. Catalyst- and organic solvent-free synthesis of thioacids in water

    Article • Tetrahedron Letters, July 2019, Elsevier

    Professor Bahaa Elgendy

  38. Baclofen impurities: Facile synthesis and novel environmentally benign chromatographic method for their simultaneous determination in baclofen

    Article • Biomedical Chromatography, June 2019, Wiley

    Professor Bahaa Elgendy

  39. Identification of novel small molecule inhibitors against the NS3/4A protease of hepatitis C virus genotype 4a

    Article • Current Pharmaceutical Design, February 2019, Bentham Science Publishers

    Professor Bahaa Elgendy

  40. Development of novel liver X receptor modulators based on a 1,2,4-triazole scaffold

    Article • Bioorganic & Medicinal Chemistry Letters, February 2019, Elsevier

    Professor Bahaa Elgendy

  41. Synthesis and Characterization of Carbon Steel Corrosion Inhibitors Based on 4,5,6,7-tetrahydrobenzo[b]thiophene Scaffold

    Article • Protection of Metals and Physical Chemistry of Surfaces, January 2019, Pleiades Publishing Ltd

    Professor Bahaa Elgendy

  42. Synthesis and Evaluation of Troponoids as a New Class of Antibiotics

    Article • ACS Omega, November 2018, American Chemical Society (ACS)

    Professor Bahaa Elgendy

  43. Recent Advances in the Medicinal Chemistry of Liver X Receptors

    Article • Journal of Medicinal Chemistry, July 2018, American Chemical Society (ACS)

    Professor Bahaa Elgendy

  44. Identification of 4-isopropyl–thiotropolone as a novel anti-microbial: regioselective synthesis, NMR characterization, and biological evaluation

    Article • RSC Advances, January 2018, Royal Society of Chemistry

    Professor Bahaa Elgendy

  45. P450 3A-Catalyzed O-Dealkylation of Lapatinib Induces Mitochondrial Stress and Activates Nrf2

    Article • Chemical Research in Toxicology, April 2016, American Chemical Society (ACS)

    Professor Bahaa Elgendy

  46. Investigation of adsorption and inhibition effects of some novel anil compounds towards mild steel in H2SO4 solution: Electrochemical and theoretical quantum studies

    Article • Journal of Electroanalytical Chemistry, December 2015, Elsevier

    Dr ِِAhmed Mohammed Abu-Dief, Professor Bahaa Elgendy

  47. Antibacterial activity of diketopiperazines isolated from a marine fungus using t-butoxycarbonyl group as a simple tool for purification

    Article • Bioorganic & Medicinal Chemistry Letters, August 2015, Elsevier

    Professor Bahaa Elgendy

  48. Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis

    Article • Cancer Cell, July 2015, Elsevier

    Professor Bahaa Elgendy

  49. Stereoselective Synthesis, Structural and Spectroscopic Study of 4,5,11-Triazatricyclo[6.2.1.0*2,6*]Undec-5-ene

    Article • Journal of Heterocyclic Chemistry, June 2015, Wiley

    elsayed shalaby, Professor Bahaa Elgendy

  50. Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour

    Article • Nature Communications, December 2014, Springer Science + Business Media

    Professor Bahaa Elgendy

  51. Regioselective synthesis, stereochemical structure, spectroscopic characterization and geometry optimization of dispiro[3H-indole-3,2′-pyrrolidine-3′,3″-piperidines]

    Article • Journal of Molecular Structure, October 2014, Elsevier

    Dr Ahmed F Mabied, elsayed shalaby, Professor Bahaa Elgendy

  52. Pyrrolizines: Promising scaffolds for anticancer drugs

    Article • Bioorganic & Medicinal Chemistry, January 2014, Elsevier

    Professor Bahaa Elgendy

  53. α-Substitution Effects on the Ease ofS→N-Acyl Transfer in Aminothioesters

    Article • Chemical Biology & Drug Design, April 2013, Wiley

    Girinath G. Pillai, PhD, Dr Ebrahim H Ghazvini Zadeh, Professor Bahaa Elgendy

  54. Small molecule amides as potent ROR-γ selective modulators

    Article • Bioorganic & Medicinal Chemistry Letters, January 2013, Elsevier

    Professor Bahaa Elgendy

  55. A Liver-Selective LXR Inverse Agonist That Suppresses Hepatic Steatosis

    Article • ACS Chemical Biology, December 2012, American Chemical Society (ACS)

    Professor Bahaa Elgendy

  56. Synthesis of Benzoxazines, Quinazolines and 4H-Benzo[e][1,3]thiazine by ANRORC Rearrangements of 1,2,4-Oxadiazoles

    Article • Synthesis, January 2012, Thieme Publishing Group

    Professor Bahaa Elgendy

  57. Synthesis of chiral α-amino acid-derived 1H-1,2,4-triazoles and 1,2,4-triazines

    Article • MedChemComm, January 2012, Royal Society of Chemistry

    Dr Ebrahim H Ghazvini Zadeh, Professor Bahaa Elgendy

  58. Cyclohexanol analogues are positive modulators of GABAA receptor currents and act as general anaesthetics in vivo

    Article • European Journal of Pharmacology, September 2011, Elsevier

    Professor Bahaa Elgendy

  59. Synthesis and photochemistry of pH-sensitive GFP chromophore analogs

    Article • Tetrahedron Letters, April 2011, Elsevier

    Professor Bahaa Elgendy

  60. Efficient microwave-assisted synthesis of aminoxy acid conjugates

    Article • RSC Advances, January 2011, Royal Society of Chemistry

    Professor Bahaa Elgendy

  61. NMR Study of the Tautomeric Behavior of N-(α-Aminoalkyl)tetrazoles

    Article • The Journal of Organic Chemistry, September 2010, American Chemical Society (ACS)

    Professor Bahaa Elgendy

  62. Tautomerism in drug discovery

    Article • Journal of Computer-Aided Molecular Design, May 2010, Springer Science + Business Media

    Professor Bahaa Elgendy

  63. 1H, 13C, and 15N NMR spectra of some pyridazine derivatives

    Article • Magnetic Resonance in Chemistry, March 2010, Wiley

    Professor Bahaa Elgendy

  64. Conformational equilibria and barriers to rotation in some novel nitroso derivatives of indolizines and 3- and 5-azaindolizines – an NMR and molecular modeling study

    Article • Organic & Biomolecular Chemistry, January 2010, Royal Society of Chemistry

    Professor Bahaa Elgendy

  65. Selective Synthesis and Structural Elucidation of S-Acyl- and N-Acylcysteines

    Article • The Journal of Organic Chemistry, August 2009, American Chemical Society (ACS)

    Professor Bahaa Elgendy

  66. Tautomerism of guanidines studied by 15N NMR: 2-hydrazono-3-phenylquinazolin-4(3H)-ones and related compounds

    Article • Organic & Biomolecular Chemistry, January 2009, Royal Society of Chemistry

    Professor Bahaa Elgendy

  67. (α-Aminoacyl)amino-Substituted Heterocycles and Related Compounds

    Article • The Journal of Organic Chemistry, June 2008, American Chemical Society (ACS)

    Professor Bahaa Elgendy

  68. Benzotriazole-mediated alkoxyalkylation and acyloxyalkylation

    Article • Tetrahedron, July 2007, Elsevier

    Professor Bahaa Elgendy