All Stories

  1. Pioneering Metal‐Free Late‐Stage C‐H Functionalization Using Acridinium Salt Photocatalysis

    Article • Chemistry - A European Journal, August 2024, Wiley

    Professor Andrea Porcheddu

  2. Mechanochemistry in Organic Synthesis: An Italian Journey through Innovations

    Article • European Journal of Organic Chemistry, July 2024, Wiley

    Professor Andrea Porcheddu

  3. Efficient, Facile, and Green Synthesis of Ruthenium Carboxylate Complexes by Manual Grinding

    Article • Processes, July 2024, MDPI AG

    Professor Andrea Porcheddu

  4. Unveiling the Untapped Potential of Bertagnini’s Salts in Microwave-Assisted Synthesis of Quinazolinones

    Article • Molecules, April 2024, MDPI AG

    Professor Andrea Porcheddu

  5. Application of Bertagnini's Salts in a Mechanochemical Approach Toward Aza‐Heterocycles and Reductive Aminations via Imine Formation

    Article • Advanced Synthesis & Catalysis, March 2024, Wiley

    Professor Andrea Porcheddu

  6. Visible Light-Promoted Oxidative Cross-Coupling of Alcohols to Esters

    Article • Molecules, January 2024, MDPI AG

    Professor Andrea Porcheddu

  7. Mechanically accelerated catalytic hydrogenation: correlating physical state, reaction rate, and interface area

    Article • Green Chemistry, January 2024, Royal Society of Chemistry

    Professor Andrea Porcheddu

  8. Mechanosynthesis of sulfonamides via a telescopic, environmentally friendly, and cost-effective process

    Article • Green Chemistry, January 2024, Royal Society of Chemistry

    Professor Andrea Porcheddu

  9. Mechanically processed Sardinian wool promotes C–C bond synthesis under solvent-free conditions

    Article • RSC Sustainability, January 2024, Royal Society of Chemistry

    Professor Andrea Porcheddu

  10. Mechanochemistry for Healthcare: Revealing the Nitroso Derivatives Genesis in the Solid State

    Article • ChemSusChem, November 2023, Wiley

    Professor Andrea Porcheddu

  11. Ammonia Synthesis by Mechanochemistry

    Article • ChemCatChem, August 2023, Wiley

    Professor Andrea Porcheddu

  12. Mechanochemistry Frees Thiourea Dioxide (TDO) from the ‘Veils’ of Solvent, Exposing All Its Reactivity

    Article • Molecules, February 2023, MDPI AG

    Professor Andrea Porcheddu

  13. A Visible‐Light Driven Esterification of Aldehydes Catalyzed by VOSO 4

    Article • Advanced Synthesis & Catalysis, February 2023, Wiley

    Professor Andrea Porcheddu

  14. Mechanochemistry Frees the Thiourea Dioxide (TDO) from the ‘Veils’ of the Solvent, Exposing All Its Reactivity

    Article • February 2023, MDPI AG

    Professor Andrea Porcheddu

  15. Green metrics in mechanochemistry

    Article • Chemical Society Reviews, January 2023, Royal Society of Chemistry

    Professor Andrea Porcheddu

  16. N-Alkylation of aromatic amines with alcohols by using a commercially available Ru complex under mild conditions

    Article • RSC Advances, January 2023, Royal Society of Chemistry

    Professor Andrea Porcheddu

  17. From amines to (form)amides: a simple and successful mechanochemical approach

    Article • Beilstein Journal of Organic Chemistry, September 2022, Beilstein Institut

    Professor Andrea Porcheddu

  18. N-Formylsaccharin: A Sweet(able) Formylating Agent in Mechanochemistry

    Article • Molecules, August 2022, MDPI AG

    Professor Andrea Porcheddu

  19. Mechanochemistry: New Tools to Navigate the Uncharted Territory of “Impossible” Reactions

    Article • ChemSusChem, July 2022, Wiley

    Professor Andrea Porcheddu

  20. N-Formylsaccharin: A Sweet(able) Formylating Agent in Mechanochemistry

    Article • July 2022, MDPI AG

    Professor Andrea Porcheddu

  21. A trustworthy mechanochemical route to isocyanides

    Article • Beilstein Journal of Organic Chemistry, June 2022, Beilstein Institut

    Professor Andrea Porcheddu

  22. A Trustworthy Mechanochemical Route to Isocyanides: The Handyman of Chemistry

    Article • April 2022, Beilstein Institut

    Professor Andrea Porcheddu

  23. Appealing Renewable Materials in Green Chemistry

    Article • Molecules, March 2022, MDPI AG

    Professor Andrea Porcheddu

  24. Mechanochemistry Can Reduce Life Cycle Environmental Impacts of Manufacturing Active Pharmaceutical Ingredients

    Article • ACS Sustainable Chemistry & Engineering, January 2022, American Chemical Society (ACS)

    Professor Andrea Porcheddu

  25. Mechanochemical Fischer indolisation: an eco-friendly design for a timeless reaction

    Article • Green Chemistry, January 2022, Royal Society of Chemistry

    Professor Andrea Porcheddu

  26. Adsorption and Release of Sulfamethizole from Mesoporous Silica Nanoparticles Functionalised with Triethylenetetramine

    Article • International Journal of Molecular Sciences, July 2021, MDPI AG

    Professor Andrea Porcheddu

  27. Mechanochemical Rearrangements

    Article • The Journal of Organic Chemistry, July 2021, American Chemical Society (ACS)

    Professor Andrea Porcheddu, Dr felipe Garcia

  28. The Mechanochemical Beckmann Rearrangement: An Eco-efficient “Cut-and-Paste” Strategy to Design the “Good Old Amide Bond”

    Article • ACS Sustainable Chemistry & Engineering, January 2021, American Chemical Society (ACS)

    Professor Andrea Porcheddu

  29. Solvent‐free Reactions for the Synthesis of Indolenine‐based Squaraines and Croconaines: Comparison of Thermal Heating, Mechanochemical Milling, and IR Irradiation

    Article • ChemSusChem, January 2021, Wiley

    Professor Andrea Porcheddu

  30. Coupling of mechanical deformation and reaction in mechanochemical transformations

    Article • Physical Chemistry Chemical Physics, January 2021, Royal Society of Chemistry

    Professor Andrea Porcheddu

  31. A phenomenological kinetic equation for mechanochemical reactions involving highly deformable molecular solids

    Article • Physical Chemistry Chemical Physics, January 2021, Royal Society of Chemistry

    Professor Andrea Porcheddu

  32. Kabachnik–Fields Reaction by Mechanochemistry: New Horizons from Old Methods

    Article • ACS Sustainable Chemistry & Engineering, December 2020, American Chemical Society (ACS)

    Professor Andrea Porcheddu

  33. Mechanochemical Preparation of Active Pharmaceutical Ingredients Monitored by In Situ Raman Spectroscopy

    Article • ACS Omega, October 2020, American Chemical Society (ACS)

    Professor Andrea Porcheddu

  34. Solvent-Free, Continuous Synthesis of Hydrazone-Based Active Pharmaceutical Ingredients by Twin-Screw Extrusion

    Article • ACS Sustainable Chemistry & Engineering, August 2020, American Chemical Society (ACS)

    Professor Andrea Porcheddu

  35. Visible-Light Photoredox-Catalyzed Amidation of Benzylic Alcohols

    Article • The Journal of Organic Chemistry, July 2020, American Chemical Society (ACS)

    Professor Andrea Porcheddu

  36. Metal-Mediated and Metal-Catalyzed Reactions Under Mechanochemical Conditions

    Article • ACS Catalysis, July 2020, American Chemical Society (ACS)

    Professor Andrea Porcheddu

  37. Kinetics of mechanochemical transformations

    Article • Physical Chemistry Chemical Physics, January 2020, Royal Society of Chemistry

    Professor Andrea Porcheddu

  38. Simple squaramide receptors for highly efficient anion binding in aqueous media and transmembrane transport

    Article • Chemical Communications, January 2020, Royal Society of Chemistry

    Professor Andrea Porcheddu

  39. Metal-free mechanochemical oxidations in Ertalyte® jars

    Article • Beilstein Journal of Organic Chemistry, July 2019, Beilstein Institut

    Professor Andrea Porcheddu

  40. From Lossen Transposition to Solventless “Medicinal Mechanochemistry”

    Article • ACS Sustainable Chemistry & Engineering, June 2019, American Chemical Society (ACS)

    Professor Andrea Porcheddu

  41. From enabling technologies to medicinal mechanochemistry: an eco-friendly access to hydantoin-based active pharmaceutical ingredients

    Article • Reaction Chemistry & Engineering, January 2019, Royal Society of Chemistry

    Professor Andrea Porcheddu

  42. Visible light-induced transformation of aldehydes to esters, carboxylic anhydrides and amides

    Article • New Journal of Chemistry, January 2019, Royal Society of Chemistry

    Professor Andrea Porcheddu

  43. Processing and Investigation Methods in Mechanochemical Kinetics

    Article • ACS Omega, August 2018, American Chemical Society (ACS)

    Professor Andrea Porcheddu

  44. Ball-milling and cheap reagents breathe green life into the one hundred-year-old Hofmann reaction

    Article • Organic Chemistry Frontiers, January 2018, Royal Society of Chemistry

    Professor Andrea Porcheddu

  45. High throughput mechanochemistry: application to parallel synthesis of benzoxazines

    Article • Chemical Communications, January 2018, Royal Society of Chemistry

    Professor Andrea Porcheddu

  46. Mechanochemistry for “no solvent, no base” preparation of hydantoin-based active pharmaceutical ingredients: nitrofurantoin and dantrolene

    Article • Green Chemistry, January 2018, Royal Society of Chemistry

    Professor Andrea Porcheddu

  47. Front Cover: A Mechanochemical-Assisted Oxidation of Amines to Carbonyl Compounds and Nitriles (Eur. J. Org. Chem. /2017)

    Article • European Journal of Organic Chemistry, September 2017, Wiley

    Professor Andrea Porcheddu

  48. Synthesis of Nitric Oxide Donors Derived from Piloty’s Acid and Study of Their Effects on Dopamine Secretion from PC12 Cells

    Article • Pharmaceuticals, September 2017, MDPI AG

    Professor Andrea Porcheddu

  49. A Mechanochemical-Assisted Oxidation of Amines to Carbonyl Compounds and Nitriles

    Article • European Journal of Organic Chemistry, August 2017, Wiley

    Professor Andrea Porcheddu

  50. Anhydrides from aldehydes or alcohols via oxidative cross-coupling

    Article • New Journal of Chemistry, January 2017, Royal Society of Chemistry

    Professor Andrea Porcheddu

  51. Metal-Free Oxidative Cross Esterification of AlcoholsviaAcyl Chloride Formation

    Article • Advanced Synthesis & Catalysis, January 2016, Wiley

    Professor Andrea Porcheddu

  52. Metal-Free Direct Oxidation of Aldehydes to Esters Using TCCA

    Article • Organic Letters, August 2015, American Chemical Society (ACS)

    Professor Andrea Porcheddu

  53. A Mild and Efficient Synthesis of Substituted Quinolinesviaa Cross-Dehydrogenative Coupling of (Bio)available Alcohols and Aminoarenes

    Article • Advanced Synthesis & Catalysis, January 2015, Wiley

    Professor Andrea Porcheddu

  54. A Metal-Catalyzed Tandem 1,4-Benzodiazepine Synthesis Based on Two Hydrogen-Transfer Reactions

    Article • European Journal of Organic Chemistry, December 2014, Wiley

    Professor Andrea Porcheddu

  55. One-Pot Synthesis of Hydroxamic Acids from Aldehydes and Hydroxylamine

    Article • Advanced Synthesis & Catalysis, June 2014, Wiley

    Professor Andrea Porcheddu

  56. Synthesis of α,β-Unsaturated Aldehydes Based on a One-Pot Phase-Switch Dehydrogenative Cross-Coupling of Primary Alcohols

    Article • Organic Letters, May 2014, American Chemical Society (ACS)

    Professor Andrea Porcheddu

  57. A two-step tandem reaction to prepare hydroxamic acids directly from alcohols

    Article • Organic & Biomolecular Chemistry, January 2014, Royal Society of Chemistry

    Lidia De Luca, Professor Andrea Porcheddu

  58. “Quick and click” assembly of functionalised indole rings via metal-promoted cyclative tandem reactions

    Article • RSC Advances, January 2014, Royal Society of Chemistry

    Professor Andrea Porcheddu, Professor Andrea Porcheddu

  59. Palladium-Catalysed Dehydrogenative Generation of Imines from Amines. A Nature-Inspired Route to IndolesviaCross-Couplings of Amines with Arylhydrazines

    Article • Advanced Synthesis & Catalysis, October 2013, Wiley

    Professor Andrea Porcheddu

  60. Use of Primary Amines for the Selective N-Alkylation of Anilines by a Reusable Heterogeneous Catalyst

    Article • Synlett, September 2013, Thieme Publishing Group

    Professor Andrea Porcheddu

  61. Iron-catalysed oxidative amidation of alcohols with amines

    Article • Organic & Biomolecular Chemistry, January 2013, Royal Society of Chemistry

    Professor Andrea Porcheddu

  62. A copper-catalysed amidation of aldehydes via N-hydroxysuccinimide ester formation

    Article • Organic & Biomolecular Chemistry, January 2013, Royal Society of Chemistry

    Lidia De Luca, Professor Andrea Porcheddu

  63. From Alcohols to Indoles: A Tandem Ru Catalyzed Hydrogen-Transfer Fischer Indole Synthesis

    Article • Organic Letters, December 2012, American Chemical Society (ACS)

    Professor Andrea Porcheddu

  64. Formic Acid: A Promising Bio-Renewable Feedstock for Fine Chemicals

    Article • Advanced Synthesis & Catalysis, November 2012, Wiley

    Professor Andrea Porcheddu

  65. New Pentamidine Analogues in Medicinal Chemistry

    Article • Current Medicinal Chemistry, November 2012, Bentham Science Publishers

    Professor Andrea Porcheddu

  66. Iron-Catalyzed Amidation of Aldehydes withN-Chloroamines

    Article • Advanced Synthesis & Catalysis, October 2012, Wiley

    Professor Andrea Porcheddu

  67. One-Pot Synthesis of Amides from Aldehydes and Amines via C–H Bond Activation

    Article • Organic Letters, October 2012, American Chemical Society (ACS)

    Professor Andrea Porcheddu

  68. A General Approach to Substituted Benzimidazoles and Benzoxazoles via Heterogeneous Palladium-Catalyzed Hydrogen-Transfer with Primary Amines

    Article • Advanced Synthesis & Catalysis, August 2012, Wiley

    Professor Andrea Porcheddu

  69. Microwave-Assisted Synthesis of Polysubstituted Benzimidazoles by Heterogeneous Pd-Catalyzed Oxidative C-H Activation of Tertiary Amines

    Article • European Journal of Organic Chemistry, September 2011, Wiley

    Professor Andrea Porcheddu

  70. Synthesis and characterization of the chemical properties of new classes of NO donors as potential dopamine releasers in the treatment of Parkinson's disease

    Article • Current Opinion in Biotechnology, September 2011, Elsevier

    Professor Pier Andrea Serra, Professor Andrea Porcheddu

  71. A fast and efficient one-pot microwave assisted synthesis of variously di-substituted 1,2,4-oxadiazoles

    Article • Organic & Biomolecular Chemistry, January 2011, Royal Society of Chemistry

    Lidia De Luca, Professor Andrea Porcheddu

  72. Microwave-Promoted Selective Mono-N-Alkylation of Anilines with Tertiary Amines by Heterogeneous Catalysis

    Article • Chemistry - A European Journal, November 2010, Wiley

    Professor Andrea Porcheddu

  73. Microwave-Assisted Synthesis of N-Monosubstituted Urea Derivatives

    Article • Synlett, September 2010, Thieme Publishing Group

    Professor Andrea Porcheddu

  74. Nucleophile Cleavable Linker Units

    Article • December 2009, Wiley

    Professor Andrea Porcheddu

  75. A Mild and Inexpensive Procedure for the Synthesis of N,N′-Di-Boc-Protected Guanidines

    Article • Synlett, November 2009, Thieme Publishing Group

    Professor Andrea Porcheddu

  76. A Straightforward Route to Piloty’s Acid Derivatives: A Class of Potential Nitroxyl-Generating Prodrugs

    Article • Synlett, July 2009, Thieme Publishing Group

    Professor Andrea Porcheddu

  77. Parallel Synthesis of Trisubstituted Formamidines: A Facile and Versatile Procedure

    Article • Journal of Combinatorial Chemistry, January 2009, American Chemical Society (ACS)

    Professor Andrea Porcheddu

  78. Some Recent Approaches to the Synthesis of 2-Substituted Benzofurans

    Article • Current Medicinal Chemistry, January 2009, Bentham Science Publishers

    Professor Andrea Porcheddu

  79. A Practical and Efficient Approach to PNA Monomers Compatible with Fmoc-Mediated Solid-Phase Synthesis Protocols

    Article • European Journal of Organic Chemistry, December 2008, Wiley

    Professor Andrea Porcheddu, Dr Mariolino Carta

  80. Angeli−Rimini's Reaction on Solid Support:  A New Approach to Hydroxamic Acids

    Article • The Journal of Organic Chemistry, September 2006, American Chemical Society (ACS)

    Professor Andrea Porcheddu

  81. Synthesis of 1-Alkyl-4-imidazolecarboxylates:  A Catch and Release Strategy

    Article • Journal of Combinatorial Chemistry, November 2005, American Chemical Society (ACS)

    Professor Andrea Porcheddu

  82. Peptide Nucleic Acids (PNAs), A Chemical Overview

    Article • Current Medicinal Chemistry, October 2005, Bentham Science Publishers

    Professor Andrea Porcheddu

  83. Microwave-Assisted Synthesis of Isonitriles:  A General Simple Methodology

    Article • The Journal of Organic Chemistry, March 2005, American Chemical Society (ACS)

    Professor Andrea Porcheddu

  84. New Cellulose-Supported Reagent: A Sustainable Approach to Guanidines

    Article • Organic Letters, December 2004, American Chemical Society (ACS)

    Professor Andrea Porcheddu

  85. A New Polymer-Supported Reagent for the Synthesis of β-Lactams in Solution

    Article • The Journal of Organic Chemistry, December 2004, American Chemical Society (ACS)

    Professor Andrea Porcheddu

  86. [1,3,5]-Triazine: A Versatile Heterocycle in Current Applications of Organic Chemistry

    Article • Current Organic Chemistry, October 2004, Bentham Science Publishers

    Professor Andrea Porcheddu

  87. A New, Simple Procedure for the Synthesis of Formyl Amides

    Article • Synlett, September 2004, Thieme Publishing Group

    Professor Andrea Porcheddu

  88. Colorimetric Tools for Solid-Phase Organic Synthesis

    Article • Journal of Combinatorial Chemistry, September 2004, American Chemical Society (ACS)

    Professor Andrea Porcheddu

  89. A Mild Procedure for the Preparation of 3-Aryl-4-formylpyrazoles

    Article • Synlett, January 2004, Thieme Publishing Group

    Professor Andrea Porcheddu

  90. A “Catch and Release” Strategy for the Parallel Synthesis of 2,4,5-Trisubstituted Pyrimidines

    Article • Journal of Combinatorial Chemistry, January 2004, American Chemical Society (ACS)

    Professor Andrea Porcheddu

  91. Simple One-Flask Method for the Preparation of Hydroxamic Acids

    Article • Organic Letters, July 2003, American Chemical Society (ACS)

    Professor Andrea Porcheddu

  92. Cellulose Beads:  a New Versatile Solid Support for Microwave- Assisted Synthesis. Preparation of Pyrazole and Isoxazole Libraries

    Article • Journal of Combinatorial Chemistry, July 2003, American Chemical Society (ACS)

    Professor Andrea Porcheddu

  93. A method for generating nitrile oxides from nitroalkanes: a microwave assisted route for isoxazoles

    Article • Tetrahedron, July 2003, Elsevier

    Professor Andrea Porcheddu

  94. Trichloroisocyanuric/TEMPO Oxidation of Alcohols under Mild Conditions:  A Close Investigation

    Article • The Journal of Organic Chemistry, June 2003, American Chemical Society (ACS)

    Professor Andrea Porcheddu

  95. Preparation of pyrazole and isoxazole libraries on cellulose beads: a new cheap and versatile biopolymer

    Article • Comptes Rendus Chimie, May 2003, Elsevier

    Professor Andrea Porcheddu

  96. Beckmann Rearrangement of Oximes under Very Mild Conditions

    Article • The Journal of Organic Chemistry, August 2002, American Chemical Society (ACS)

    Professor Andrea Porcheddu

  97. Mild and Highly Selective Formyl Protection of Primary Hydroxyl Groups

    Article • The Journal of Organic Chemistry, July 2002, American Chemical Society (ACS)

    Professor Andrea Porcheddu

  98. An Efficient Route to Alkyl Chlorides from Alcohols Using the Complex TCT/DMF

    Article • Organic Letters, February 2002, American Chemical Society (ACS)

    Professor Andrea Porcheddu

  99. A Mild and Efficient Alternative to the Classical Swern Oxidation

    Article • The Journal of Organic Chemistry, November 2001, American Chemical Society (ACS)

    Professor Andrea Porcheddu

  100. A Very Mild and Chemoselective Oxidation of Alcohols to Carbonyl Compounds

    Article • Organic Letters, September 2001, American Chemical Society (ACS)

    Professor Andrea Porcheddu

  101. A Simple Preparation of Ketones. N -Protected α-Amino Ketones from α-Amino Acids

    Article • Organic Letters, May 2001, American Chemical Society (ACS)

    Professor Andrea Porcheddu

  102. Small Ring Constrained Peptidomimetics. Synthesis of Epoxy Peptidomimetics, Inhibitors of Cysteine Proteases

    Article • The Journal of Organic Chemistry, February 2001, American Chemical Society (ACS)

    Professor Andrea Porcheddu

  103. New pyrazole containing bicarboxylic α-amino acids: mimics of the cis amide bond

    Article • Tetrahedron Letters, December 1999, Elsevier

    Professor Andrea Porcheddu

  104. A Simple Method for the Reduction of Carboxylic Acids to Aldehydes or Alcohols Using H 2 and Pd/C

    Article • The Journal of Organic Chemistry, November 1999, American Chemical Society (ACS)

    Professor Andrea Porcheddu

  105. Mild reduction of carboxylic acids to alcohols using cyanuric chloride and sodium borohydride

    Article • Tetrahedron Letters, June 1999, Elsevier

    Professor Andrea Porcheddu

  106. New 1,3,5-triazine derivatives as templates for the homogeneous phase synthesis of chemical libraries

    Article • Tetrahedron Letters, October 1998, Elsevier

    Professor Andrea Porcheddu

  107. General approach to the synthesis of optically active 2-carboxy-4-[′3-(diethoxyphosphinyl)propyl]-5-alkylperazines (CCP analogues)

    Article • Tetrahedron Asymmetry, May 1997, Elsevier

    Professor Andrea Porcheddu

  108. Synthesis of (2R, 5S)- and (2S, 5S)-2-carboxy-1,4-diaza-[4.3.0]bicyclononane as building blocks for the synthesis of new potential HIV protease inhibitors

    Article • Tetrahedron Asymmetry, July 1996, Elsevier

    Professor Andrea Porcheddu