What is it about?
Diabetes is a significant health problem that has reached worrisome proportions: almost half of the world's population now has diabetes. Diabetes mellitus, or diabetes, is a severe, long-term disease in which a person's blood glucose levels are elevated due to their body's inability to make any or enough insulin, or to properly utilise the insulin that it does produce. The chemicals extracted from medicinal plants were shown to be both safer and more bioactive than manufactured medicines.Objective:The goal of this research was to use molecular docking to find possible binding affinities of luteolin, a phytocompound from Rumex vesicariusL, to five target proteins, in order to find the lead molecule against diabetes.
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Why is it important?
Sulfonylureas, meglitinides, biguanides, thiazolidinediones, and alpha glycosidase inhibitors are among the five types of oral hypoglycemics now available, with others in clinical trials, such as protein tyrosine phosphatase-1 beta inhibitors . Many studies have been published in the past few years that fully explain and prove the use of natural products in anti-diabetic therapy, including papers on Chinese medicinal plant-derived therapeutic compounds, flavonoids, and desert plants . WHO has identified over 21,000 plants having significant therapeutic potential all over the globe, including 2500 species in India, of which 150 species are economically utilised on a big basis . The World Health Organization Committee on Diabetes' suggestion to encourage research on hypoglycemic drugs of plant origin used in traditional medicine has sparked a lot of interest in this field . According to a literature review, over 800 plants have been utilised for empirical diabetes treatment, with one tenth of them classified as hypoglycaemic plants containing active components such as glycans, flavonoids, Triterpenes, and alkaloids .
Perspectives
luteolin has the potential to be a medication for the treatment of diabetes mellitus. Because luteolin binds to alpha Amylase and DPP4 effectively, it may be involved in preventing glucose synthesis. It also binds to GFAT1 and FOX01, suggesting that it may help to avoid hyperglycemia. The great efficiency with which luteolin binds to alpha glucosidase suggests that it has a function in preventing glucose synthesis. As a result of the in silico molecular docking analysis, luteolin isthe best recommended medication, and it may serve as a powerful inhibitor against type 2 Diabetes mellitus targets. We believe that this phytochemical, luteolin, may be utilised in preclinical studies as an anti-diabetic drug to combat diabetes mellitus.
Rakesh Davella
Kakatiya University
Read the Original
This page is a summary of: Luteolin: A Potential Multiple Targeted Drug Effectively Inhibits Diabetes Mellitus Protein Targets, Journal of Pharmaceutical Research International, September 2021, Sciencedomain International,
DOI: 10.9734/jpri/2021/v33i44b32661.
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