What is it about?
Nano-carriers have been use as drug delivery systems in a plethora of conditions. Yet, nanoparticles interact with cells, and get eaten by them, whether they have a ligand for a receptor to the cell's surface or not. How can be sure that nanoparticles do interact with the right receptor?. Here we discuss and experimentally test what is needed to assure such interactions occur.
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Why is it important?
Because many studies using ligand-coated nanoparticles have ignored the issue, partly because the lack of tools and understanding of cell biology. The work is additionally important as many reports in nanoparticles targeting have no solid evidence of targeting and rather downstream effects. We cover one of the biggest problems in nanomedicine which is targetability.
Perspectives
We show that it is possible to target specific receptors but it is not trivial
Professor Adolfo Rivero-Muller
Uniwersytet Medyczny w Lublinie
Read the Original
This page is a summary of: Targeting Somatostatin Receptors By Functionalized Mesoporous Silica Nanoparticles - Are We Striking Home?, Nanotheranostics, January 2018, Ivyspring International Publisher,
DOI: 10.7150/ntno.23826.
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