Citrus Fruit Compounds Boost Athletic Performance and Heart Health

What is it about?

The study reviewed clinical trials investigating the effects of Citrus sinensis flavanones, primarily hesperidin and narirutin, on athletic performance and cardio-metabolic health. The methodology involved a narrative review of literature sourced from PubMed, ScienceDirect, Google Scholar, and Publons, focusing on randomized controlled trials, crossover, or controlled cohort studies from 2010 to 2023. The research found that C. sinensis flavanones enhance exercise output, increase anaerobic power, and improve biomarkers related to muscle fatigue, oxidative stress, and inflammation. Key mechanistic insights include increased endogenous antioxidant capacity, downregulation of pro-inflammatory cytokines, and improved endothelial function. The study also highlighted significant improvements in blood pressure regulation and lipid profiles, showcasing reductions in systolic and diastolic blood pressure, LDL cholesterol, and triglycerides. Overall, the research confirms the efficacy of C. sinensis flavanones in supporting athletic performance and cardio-metabolic health through various physiological mechanisms.

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Why is it important?

This study is important as it explores the potential of Citrus sinensis flavanones, such as hesperidin and narirutin, to significantly enhance athletic performance and cardio-metabolic health. By focusing on the natural bioactive compounds found in C. sinensis, the research highlights an evidence-based approach to improving oxidative stress management, inflammation reduction, and endothelial function, which are critical for both athletes and the general population. This study underscores the relevance of integrating natural flavanones into sports nutrition and wellness strategies, offering a safer and multifaceted alternative to synthetic performance enhancers. The research paves the way for developing functional foods and dietary supplements that could benefit individuals engaged in high-intensity exercise or those with metabolic disorders, ultimately contributing to improved health and performance outcomes. Key Takeaways: 1. Athletic Performance Enhancement: The study finds that C. sinensis flavanones, particularly hesperidin, significantly improve exercise output and anaerobic power, as well as positively influence biomarkers related to muscle fatigue and recovery. 2. Cardiovascular and Metabolic Benefits: Clinical trials indicate that supplementation with C. sinensis flavanones leads to notable improvements in blood pressure regulation and lipid profiles, including reductions in systolic and diastolic blood pressure, LDL-C, and triglycerides. 3. Mechanistic Insights: The research reveals that the beneficial effects of C. sinensis flavanones are mediated through enhanced antioxidant capacity, suppression of pro-inflammatory cytokines, and improved endothelial function, offering a comprehensive mechanism for their health-promoting activities.