Renoprotective Evaluations of Different Angiotensin Inhibitors on Diabetic Nephropathy in Rats

What is it about?

This study was designed to compare the effectiveness of different angiotensin inhibitors; direct renin inhibitor (Aliskiren), angiotensin-converting enzyme inhibitors (Ramipril) and angiotensin II receptor blocker (Irbesartan) in prevention and treatment of nephropathy in a group of rat diabetic nephropathy in rats.

Featured Image

Why is it important?

The administration of (Ramipril, Irbesartan, and Aliskiren) caused a significant reduction in blood pressure, blood glucose, serum urea, Na+ and K+ excretion rate, with a significant improvement in urine flow and glomerular filtration rate.