What is it about?
In this study, we prepared ganirelix acetate injection generic product based on the Orgalutran® authorised formulation composition and exposed it to thermal and humidity conditions for 6 months at 25°C/60%RH and 40°C/75%RH. The effect of temperature and humidity on the chemical structure of ganirelix was studied using FTIR and UV-visible spectrophotometers, and the similarity with Orgalutran® was determined.
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Why is it important?
Temperature and humidity levels can fluctuate significantly during transportation. Changes in the manufacturing process and storage environment are extremely sensitive to peptide molecules, resulting in modifications to their primary (amino acid composition and sequence) and secondary structures. Changes in the primary and secondary structure of certain peptides can have a significant impact on their biological function, so it is critical to evaluate their primary and secondary structural integrity after any processing or storage variation.
Read the Original
This page is a summary of: Applications of Fourier Transform Infrared and UV-Visible Spectroscopy for the demonstrating sameness of Ganirelix peptide in Liquid Injection Formulation, Research Journal of Pharmacy and Technology, April 2022, A and V Publications,
DOI: 10.52711/0974-360x.2022.00286.
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