What is it about?
Analysis of Efficacy of Tranexamic Acid in Reduction of Blood Loss and Postoperative Blood Transfusions Following Orthopedic Trauma Surgery
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Why is it important?
Perioperative and post-surgical hemorrhage is common in invasive surgical procedures, including orthopedic surgery. Tranexamic acid (TXA) is a pharmacologic agent that acts through an antifibrinolytic mechanism to stabilize formed clots and to reduce active bleeding. It has been used successfully in orthopedics to reduce perioperative blood loss, particularly in total hip and knee arthroplasty and spine surgery. Ischemia increases fibrinolysis, related to the proteolytic action of plasmin, with a subsequent fibrinogen scission, which limits postoperative coagulation and favors bleeding. Tranexamic acid being antifibrinolytic acts to prevent this effect from taking place. This study was designed to assess the efficacy of TXA in reducing blood loss and postoperative blood transfusions following the fixation of a fracture of both bones of the leg with intramedullary interlocking nailing of tibia done by the open method.
Perspectives
This study indicated that TXA results in a significant reduction in blood loss (nearly 60%) and the amount of blood transfusion required in patients undergoing surgery. Routine administration of TXA may benefit patients undergoing surgery where significant blood loss is expected.
Dr Sathish Muthu
Government Hospital, Velayuthampalayam, Karur, TN, India.
Read the Original
This page is a summary of: Analysis of Efficacy of Tranexamic Acid in Reduction of Blood Loss and Postoperative Blood Transfusions Following Orthopedic Trauma Surgery, January 2019, Jaypee Brothers Medical Publishing,
DOI: 10.5005/jp-journals-10079-1007.
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