Medication-related osteonecrosis of the jaws secondary to tooth extractions

What is it about?

In view of the increasing number of patients receiving antiresorptive or antiangiogenic treatment, and the important morbidity associated to osteonecrosis of the jaws (ONJ), we decided to conduct a systematic review with the purpose of identifying the most relevant protocols and best measures for preventing the development of ONJ secondary to tooth extraction

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Why is it important?

No conclusive scientific evidence is available to date on the efficacy of osteonecrosis of the jaws prevention protocols in patients subjected to tooth extraction and treated with antiresorptive or antiangiogenic drugs. In practical terms, and until future studies are able to define the ideal protocol, adoption of the preventive measures proposed by the international expert committees has weak scientific justification, but could afford some coverage from the medical-legal perspective