What is it about?
Melatonin is used in many countries to improve sleep disorders. Melatonin is a hormone produced by the pine- al gland and enterochromaffin cells which control sleep and gastrointestinal motility. Low levels of melatonin lead to gastroesophageal reflux disease (GERD). Most of patients with GERD have a sleep disorder. So, low mela- tonin levels is the main cause of insomnia. Beyond this, it has an inhibitory action on gastric acid secretion and seems to control the lower esophageal sphincter. Proton pump inhibitors (PPIs) are a group of drugs whose main action is a pronounced and long-lasting reduction of gas- tric acid production. They are the most potent inhibitors of acid secretion available today. Omeprazole (one of the PPIs) and melatonin have similarities in their chemical structures. Therefore, we could consider omeprazole as a rough copy of melatonin. In this paper, we compare the advantages and disadvantages of the clinical use of melatonin and PPIs.
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Why is it important?
This paper describes a natural formula (amino acids, vitamins and melatonin) for healing GERD, ulcer and gastritis. This combination has no side effects.
Perspectives
This formula is being produced and sold in USA with brand name PROTEXID: https://www.heranswer.com/products/333-protexid/
Ricardo de Souza Pereira
Universidade Federal do Amapa
Read the Original
This page is a summary of: Which is the best choice for gastroesophageal disorders: Melatonin or proton pump inhibitors?, World Journal of Gastrointestinal Pharmacology and Therapeutics, January 2010, Baishideng Publishing Group Co., Limited (formerly WJG Press),
DOI: 10.4292/wjgpt.v1.i5.102.
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