Neurology in the Light of Genomics: Application of NGS and GWAS in Neurological Disorders

What is it about?

This review article summarizes ample applications of NGS,GWAS and GCTA techniques on complex neurological disorders. Disease specific discussion is available in the literature, but this article attempts to amalgamate implementation of state-of-the-art latest genomics based techniques in multiple complex neurological conditions. Moreover, information on the ethical boundaries have also been discussed in this article.

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Why is it important?

Sometimes, defining a neurological or psychological condition becomes confusing clinically. Moreover, attributing such issues with relation to a patient treatment becomes more puzzling. Several neurological conditions are symptomatically or clinically overlapped and it is troublesome to distinguish them many a times. Apart from this molecular level information are not up to the mark as well. Due to the ethical considerations, lack of sample population many studies remained as inconclusive statistically as well as clinically due to overlapping results. Modern techniques such as NGS, GWAS, GCTA allowed to overcome such issues to some extent. This article summarizes such information on the implementation on various neurological or psychological disorders along with the ethical considerations. Individual reports on specific diseases are available but probably amalgamated reports are not many.