Characterization of Physical, Spectral and Thermal Properties of Biofield Treated 1,2,4-Triazole

What is it about?

Triazoles are an important class of compounds used as core molecule for the synthesis of many pharmaceutical drugs. The objective of the present research was to investigate the influence of biofield treatment on physical, spectral and thermal properties of 1,2,4-triazole. The study was performed in two groups, control and treatment. The control group remained as untreated, and biofield treatment was given to treatment group. The control and treated 1,2,4-triazole were characterized by X-ray diffraction (XRD), Differential Scanning Calorimetry (DSC), Thermo Gravimetric analysis (TGA), Surface area analyzer, and Fourier transform infrared (FT-IR) spectroscopy. XRD analysis revealed a decrease in unit cell volume of treated 1,2,4-triazole (662.08 10-24 cm3) as compared to control sample (666.34 10-24 cm3). Similarly, a decrease in molecular weight of treated 1,2,4-triazole (69.78 g/mol) with respect to control (70.23 g/mol) was observed. Additionally, a substantial decrease in crystallite size (G) was observed in treated 1,2,4-triazole by 16.34% with respect to control. DSC analysis showed a slight increase in melting temperature of treated 1,2,4-triazole (124.22°C) as compared to control (123.76°C). Moreover, a significant increase in latent heat of fusion was noticed in treated 1,2,4-triazole by 21.16% as compared to control sample. TGA analysis showed a significant increase in maximum thermal decomposition temperature (Tmax) of treated 1,2,4-triazole (213.40°C) as compared to control (199.68°C). Surface area analysis using BET showed a substantial increase in surface area of the treated compound by 13.52% with respect to control. However, FT-IR analysis showed no structural changes in treated 1,2,4-triazole with respect to control. Overall, the result showed significant alteration of physical and thermal properties of the treated 1,2,4-triazole with respect to control.

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Why is it important?

Now-a-days research is focused towards the introduction of novel and biologically safe therapeutic agents. Recently nitrogen-containing heterocycles are commonly found in most of the medicinal compounds. Triazoles are fused heterocyclic compounds that have received considerable attention owing to their synthetic and medicinal importance. Especially, 1,2,4-triazole was used as core molecule for the synthesis of different pharmacological agents such as anti-inflammatory, CNS stimulants, sedative, anti-anxiety, antimicrobial, and anti-migraine activity [1]. 1,2,4-Triazole derivatives have received considerable attention as antifungal agents such as fluconazole and itraconazole [2-4]. These compounds have advantages due to its low toxicity, high oral bioavailability and a broad spectrum of activity against several fungi [5-7]. Kurtzer, et al. reported that 4-amino-5-mercapto-3-substituted-1,2,4-triazole compound has excellent antifungal, anti-inflammatory and anti-tubercular activities that make them potential chemotherapeutic agents [8]. The chemical and physical stability of the pharmaceutical compounds are more desired quality attributes that directly affect its safety, efficacy, and shelf life [9]. Hence, it is required to explore some new alternate approach that could alter the physical and chemical properties of the compounds. Mohammadi et al. used fast neutron and gamma irradiation to investigate the thermal, structural and physical properties of an organic compound [10]. Recently biofield treatment was used as an excellent strategy for modification of spectral properties of various pharmaceutical drugs like paracetamol, piroxicam, and physicochemical properties of metals, beef extract, and meat infusion powder [11-13]. Recently it was discovered that electrical process occurring in the human body has a relation with the magnetic field. Rivera-Ruiz et al. reported that electrocardiography has been extensively used to measure the biofield of the human body [14]. According to Ampere’s law, the moving charge produces the magnetic field in surrounding space. Likewise, human body emits the electromagnetic waves in the form of bio-photons, which surrounds the body, and it is commonly known as biofield. Therefore, the biofield consists of an electromagnetic field, being generated by moving electrically charged particles (ions, cell, molecule, etc.) inside the human body. Thus, human beings have the ability to harness the energy from environment/Universe and can transmit into any object (living or non-living) around the Globe. The object(s) always receive the energy and responding in a useful manner that is called biofield energy. Mr. Trivedi’s unique biofield treatment is also known as The Trivedi Effect®. Mr. Trivedi biofield treatment is known to transform the characteristics of various living and nonliving things. The biofield treatment has improved the growth and production of agriculture crops [15-18] and significantly altered the phenotypic characteristics of various pathogenic microbes [19-21]. Additionally, biofield treatment has substantially altered the medicinal, growth and anatomical properties of ashwagandha [22]. Based on the excellent outcome from biofield treatment and interesting pharmaceutical applications of 1,2,4-Triazole, this work was undertaken to investigate the impact of biofield treatment on this compound.

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