What is it about?
We demonstrated an elegant but simple hydrophobic dye-binding method for high-throughput screening to study stability and aggregation of mAbs. Our method is faster and more sensitive than the widely used HPLC method and requires only a fraction of protein sample compared to the amount of protein needed for HPLC method.
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Why is it important?
Therapeutic monoclonal antibodies (mAbs) are increasingly becoming popular in biotech industry. Finding the ideal mAb and understanding its aggregation behaviour is utmost important to develop new therapeutics.
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This page is a summary of: Conformational stability and aggregation of therapeutic monoclonal antibodies studied with ANS and Thioflavin T binding, mAbs, July 2011, Taylor & Francis,
DOI: 10.4161/mabs.3.4.15677.
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