What is it about?
CCCP is a type of chemical called a protonophore ("bearer of protons"), which shuttles protons from one side of a membrane to the other. The ability to shuttle protons makes CCCP useful for depolarizing mitochondria, by dissipating the mitochondrial proton gradient. However, mitochondria are not the only organelle with a proton gradient. The lysosome is an acidic organelle; by definition, this means that it is full of protons. This paper showed that CCCP interferes with lysosomal function, by dissipating their acidity.
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This page is a summary of: The protonophore CCCP interferes with lysosomal degradation of autophagic cargo in yeast and mammalian cells, Autophagy, November 2013, Taylor & Francis,
DOI: 10.4161/auto.26557.
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