What is it about?
Bacterial membrane-active molecules are compound of interest for researchers working against methicillin-resistant Staphylococcus aureus (MRSA). We found a compound acting against MRSA that was screened from chemical libraries using C.elegans as an infection model. Interestingly, this compound acting potentially against MRSA at acidic pH and rescued MRSA infected wax moths as another infection model.
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Why is it important?
Due to the emergence of resistance, the world needs novel antibiotics, and our compound hasn't become resistant against MRSA after administrating for 25 days in a sequel. Hence, we propose this compound of interest warranting further development against MSRA.
Perspectives
People working from all the corners of this world against MRSA and we think this compound is little different from other MRSA antibiotics since it has the greatest ability working in acidic pH.
NAGENDRAN THARMALINGAM
Brown University
Read the Original
This page is a summary of: Activity of a novel protonophore against methicillin-resistant Staphylococcus aureus, Future Medicinal Chemistry, August 2017, Future Science,
DOI: 10.4155/fmc-2017-0047.
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