Herbomineral formulation on pro-inflammatory cytokines expression in mouse splenocyte cells

What is it about?

Current study, we investigated immunomodulatory effect of TEBEH in LPS-induced cytokines expression levels in mouse splenocytes in vitro.

Featured Image

Why is it important?

The study results summarize that TEBEH showed better and significant inhibition of pro-inflammatory cytokines (TNF-α and IL-1β) and chemokine (MIP-1α) expression as compared with the VC group in mouse splenocyte cells. In brief, the expression of MIP-1a was suppressed at all the tested concentrations. additionally, the level of IFN-γ was significantly upregulated in the highest concentration. Overall, data indicated a significant reduction of TNF-α, MIP-1a, and IL-1β and elevation of IFN-γ the pro-inflammatory mediators upon exposure with the TEBEH on splenocyte cells. In conclusion, the herbomineral-based formulation TEBEH might act as an effective anti-inflammatory product and can be used as a complementary and alternative treatment and prevention of various types of inflammatory disorders.