What is it about?
In this study, we firstly showed that TIGIT can function as a ligand for transducing signaling through its receptor CD155 expressed on stimulated naïve T cells to promote gene expression of TIGIT.
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Why is it important?
Our proposal also may highlight as how the regulatory T cells maintain their function and cell–life for long periods. At the same time, our results may be also useful to consider therapeutic methods for inducing transplantation tolerance in clinical field.
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This page is a summary of: CD155-Transducing Signaling through TIGIT Plays an Important Role in Transmission of Tolerant State and Suppression Capacity, ImmunoHorizons, November 2018, The American Association of Immunologists,
DOI: 10.4049/immunohorizons.1800033.
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