Study of the fate of photosensitizers falling into water after photochemical therapy

What is it about?

Furocoumarins (psoralens) are a dyes that can be used not only in photochemotherapy of various skin diseases (psoriasis, atopic dermatitis, rheumatoid arthritis, vitiligo), but also for photoinduced modification of nucleic acids, for phototherapy of cancer and viral infections (including HIV infections), and also in transplantology to prevent rejection of transplanted tissues.

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Why is it important?

A good degree of agreement between calculated and experimental conversion data was obtained. Based on the promising results obtained in the present work for the degradation of 5-MOP, CS5 and CS4 with excimer technology, together with a deeper knowledge of the process after validating the kinetic model, further research using continuous or semicontinuous systems and different dyes can be undertaken in the future. By fitting the experimental data to the model, a detailed study of the influence of all operational variables on the pseudo-first order kinetic parameter has been done, in good agreement with the model hypotheses.