What is it about?
The present study elucidated the pathogenesis of allergic symptoms (AS) related to contact lens (cL) wear by assaying cL care solutions in lens storage cases and tears from subjects with AS using molecular biology techniques.
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Why is it important?
contact lens (cL)‐induced papillary conjunctivitis (cLPc) is a chronic conjunctivitis that occurs in cL wearers. Physical stimulation to the palpebral conjunctiva by the cL itself and allergic reactions to substances adhering to the cL surface are considered among the primary causes. Although the types of depositions that induce an allergic reaction have not yet been confirmed, bio‐deposits of denatured protein are predicted to be one of the etiologies. Bacteria adhering to the cL surface are possible allergens for cLPc. However, this has not been investigated in depth thus far.
Perspectives
In the present study, NGS analysis of the microbiome in cL care solutions remaining in the lens storage cases and the tear fluids of CL wearers with allergic symptoms (AS) was performed. The findings of the present study suggest a possible association between bacterial contamination in the lens storage case and AS.
Prof. Hiroshi Eguchi
The University of Tokushima
Read the Original
This page is a summary of: Microbiome analysis of contact lens care solutions and tear fluids of contact lens wearers: Possible involvement of streptococcal antigens in allergic symptoms related to contact lens wear, International Journal of Molecular Medicine, July 2020, Spandidos Publications,
DOI: 10.3892/ijmm.2020.4678.
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