What is it about?
A basic genomic and proteomic analysis of the effect of a triterpenoid, madecassoside, obtainable from the commonly found plant, Centella asiatica, on neuroinflammation. This research article shows that madecassoside is capable of activating antioxidative pathways while reducing neuroinflammation via the downregulation of pro-neuroinflammatory components (e.g. iNOS, COX-2, NF-kB) at both the genomic and proteomic levels, and through the reduction of ROS level in the microglia cell culture.
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Why is it important?
It is important to highlight the importance of natural products as sources of active agents especially in areas where they are abundant. Aside from that, this research also emphasizes on the potential of using a compound known to have beneficial properties on skin health as an agent that may possibly reduce neuroinflammation.
Perspectives
This was my first research article and I am truly grateful for the guidance provided by all of the supervisors involved. Hopefully, this article can provide yet another angle when looking at neuroinflammatory processes.
Mr Andrew Octavian Sasmita
International Medical University
Read the Original
This page is a summary of: Madecassoside activates anti‑neuroinflammatory mechanisms by inhibiting lipopolysaccharide‑induced microglial inflammation, International Journal of Molecular Medicine, February 2018, Spandidos Publications,
DOI: 10.3892/ijmm.2018.3479.
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