New therapies for highly sensitized patients on the waiting list

What is it about?

This is a Review Article summarizing existing literature on new therapies for highly sensitized patients on the waiting _x000D_ list. The important points to get across are (1) HLA antibodies represent an immunologic barrier to transplantation with low rates of transplants;(2) desensitization treatment approaches need to include removal of antibody and inhibiting rebound of HLA antibody; (3) combination therapy will improve our ability to effectively desensitize patients and maintain prolonged suppression of antibody post-transplant; and (4) emerging therapies are very promising in allowing more effective desensitization for these immunologically disadvantaged patients. _x000D_

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