Outcomes Associated with Sodium-Glucose Cotransporter-2 Inhibitor Use in Acute Heart Failure Hospitalizations Complicated by Acute Kidney Injury

What is it about?

Heart failure is commonly associated with kidney injury and kidney dysfunction often makes the management of heart failure challenging. SGLT2-inhibitors are drugs that have recently shown benefits in acute decompensated heart failure. However, due to concern for worsening kidney function, SGLT2-inhibitors are often discontinued in AKI. This study aims to assess the impact of SGLT2-inhibitors in heart failure-associated AKI. In this study of adults hospitalized with heart failure complicated by kidney injury, treatment with an SGLT2 inhibitor during kidney injury was found to not prolong kidney function recovery and were associated with lower risk of in hospital death.

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