What is it about?
The highly pathogenic Ebola virus (EBOV), a member of the family Filoviridae, can enter a diverse range of cell types and only lymphocytes are known to be non-susceptible. This study shows that the cell line SH-SY5Y is resistant to entry of EBOV and other filoviruses and that entry can be restored upon expression of diverse attachment factors.
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Why is it important?
This study identifies the first adherent , non-lymphocyte human cell line resistant to filovirus infection. Moreover, it provides the first evidence that the attachment step can limit filovirus entry into target cells.
Perspectives
The cell line SH-SY5Y will be a great tool to study filovirus interactions with attachment factors (to be stably expressed in this cell line) and it will be interesting to determine whether and how filoviruses can be adapted to efficient entry into these cells.
Professor Stefan Pöhlmann
German Primate Center
Read the Original
This page is a summary of: Characterization of the Filovirus-Resistant Cell Line SH-SY5Y Reveals Redundant Role of Cell Surface Entry Factors, Viruses, March 2019, MDPI AG,
DOI: 10.3390/v11030275.
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