Is vitamin E good for bad to our bone?

What is it about?

This review summarizes the evidence on the skeletal effects of vitamin E, especially alpha-tocopherol, derived from animal and human studies. We found that moderate dose of vitamin E might not be harmful to the bone but high-dose vitamin E could be a pro-oxidant, causing oxidative damage to the bone. However, more studies need to be done to verify this speculation.

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Why is it important?

Recent studies on the adverse effects of high-dose vitamin E supplementation on bone health in rodents hit the front page of newspapers worldwide. We feel that it is necessary to clarify the issue and to delineate the skeletal effects of various vitamin E isomers.