What is it about?
This review aims to explore the mechanisms by which microbiota derived SCFAs mediate the VLCKD-infant gut microbiota relationship and its therapeutic efficacy in reducing obesity.
Featured Image
Why is it important?
The VLCKD has been proven effective as a restricted dietary pattern for treating obesity. However,its influence during pregnancy and lactation on SCFA-producing bacteria in infant gut microbiota and its mechanisms of action in the treatment of obesity are still unknown.
Perspectives
SCFAs appear to be the key microbial metabolites mediating VLCKD-infant gut microbiota relationships. Maternal VLCKD rich in PUFA, vegetable protein, dietary fibre, linoleic (ω-6) fatty acid and polyphenols stimulates the relative abundance of infant gut SCFA-producing bacteria, which may also utilize lactate as a substrate for SCFA production. Further RCTs would also be needed to elucidate the mechanisms by which SCFA-producing bacteria exert their anti-inflammatory effects in AT in early childhood.
Dr Naser Alsharairi
Griffith University
Read the Original
This page is a summary of: The Role of Short-Chain Fatty Acids in Mediating Very Low-Calorie Ketogenic Diet-Infant Gut Microbiota Relationships and Its Therapeutic Potential in Obesity, Nutrients, October 2021, MDPI AG,
DOI: 10.3390/nu13113702.
You can read the full text:
Contributors
The following have contributed to this page
