Exploring Seafood Paramyosins as Sources of Anti-Hypertensive and Anti-Diabetic Peptides

What is it about?

This paper investigates the potential of seafood paramyosins (SP) as sources of anti-angiotensin converting enzyme (ACE) and anti-dipeptidyl peptidase IV (DPP-IV) peptides. Through in silico methods, the study examines the release of these bioactive compounds from SP following gastrointestinal digestion, focusing on eight species (common octopus, Humboldt squid, Japanese abalone, Japanese scallop, Mediterranean mussel, Pacific oyster, sea cucumber, and Whiteleg shrimp) that are popularly consumed worldwide. In addition, the study predicts novel bifunctional ACE-inhibiting/DPP-IV-active peptides that could potentially be used as nutraceuticals or drug candidates targeting hypertension or diabetes.

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Photo by K. Mitch Hodge on Unsplash

Photo by K. Mitch Hodge on Unsplash

Why is it important?

• This paper contributes to the understanding of potential anti-angiotensin converting enzyme (ACE) and anti-dipeptidyl peptidase IV (DPP-IV) peptides released from seafood paramyosins following gastrointestinal digestion. • It also attempts to screen for bifunctional peptides exhibiting both ACE inhibiting and DPP-IV activities, which could be used as nutraceuticals/drug candidates targeting hypertension or diabetes. • The study focuses on eight species: common octopus, Humboldt squid, Japanese abalone, Japanese scallop Mediterranean mussel Pacific oyster sea cucumber Whiteleg shrimp that are widely consumed worldwide. • By virtually screening these proteins it aims at pinpointing promising sources of such bioactive compounds in future research studies