What is it about?
Diastereomeric imides with four chiral centers were established via Diels-Alder reaction. The imides were separated and identified by spectrometric methods associated with theoretical calculations. The phytotoxic activities of the epoxides were assessed and the imides proved to be suitable lead compounds for further investigation in the development of novel herbicides.
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Why is it important?
Cyclic imides belong to an important class of organic compounds, being particularly important in synthetic, pharmacological, and industrial chemistry. Imides are compounds with high biological potential because of their mobility across biological membranes. Imides with the electrophilic epoxide group may display even better biological potential. The synthesis and separation of the diastereomers was very efficient.
Perspectives
This work is pioneering for our group, making it possible to use this methodology for the development of new compounds with potential biological activity.
Professor Elson Santiago Alvarenga
Universidade Federal de Vicosa
Read the Original
This page is a summary of: Synthesis and Identification of Epoxy Derivatives of 5-Methylhexahydroisoindole-1,3-dione and Biological Evaluation, Molecules, March 2021, MDPI AG,
DOI: 10.3390/molecules26071923.
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