What is it about?
We tested the antifungal activity of L1 against two strains of Botrytis cinerea (B05.10, a standard laboratory strain; and A1, a wild type strains isolated from Chilean blueberries). We found that L1 acts as an efficient antifungal agent against Botrytis cinerea at 26 °C, even better than the commercial antifungal agent fenhexamid. Although the antifungal activity was also observed at 4 °C, the effect was less pronounced.
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Why is it important?
Pyridine Schiff bases present a full versatility, generally due to the substituents around the azomethine group, allowing their application in diverse areas, including the generation of antimicrobial and antifungal compounds [5,6]. Recently, pyridine Schiff bases constituted by a pyridine ring and a phenolic ring connected by an azomethine group were reported. The presence of a pyridine contributes to the antifungal activity in this kind of Schiff bases
Perspectives
These results show that small structural changes in these compounds could lead to changes in their properties. Finally, we showed that L1 exerts an antifungal effect against two strains of Botrytis cinerea (mold), including a strain isolated directly from the field, primarily at 26 °C, remarking the potential of these king of Schiff bases as modulators of biological activities.
Dr Alexander Carreño
UNAB
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This page is a summary of: Structural Characterization, DFT Calculation, NCI, Scan-Rate Analysis and Antifungal Activity against Botrytis cinerea of (E)-2-{[(2-Aminopyridin-2-yl)imino]-methyl}-4,6-di-tert-butylphenol (Pyridine Schiff Base), Molecules, June 2020, MDPI AG,
DOI: 10.3390/molecules25122741.
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