What is it about?
Extracellular vesicles represent a small miniature of the cell of origin and are implicated in cancer dissemination at distant sites. By immunoelectronmicroscopy and proteomic analysis, we studied how a milestone antibody against HER2+ breast cancers- trastuzumab- is able to modulate the number, morphology, and content of these important vehicles for cancer spreading.
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Why is it important?
Metastasis derived from primary cancer is still the major cause of death in cancer patients and extracellular vesicles represent one of the major ways for cancer cells to disseminate their oncogenic potential at distant sites in the human body. Our findings show that trastuzumab modulates 51 proteins transported by these vesicles and their morphology. All these proteins are all involved in cellular processes like membrane trafficking, organelle and lipid homeostasis, migration, and survival.
Perspectives
Writing this article was a great pleasure as it has co-authors with whom I have built a great team and long-standing collaborations. This article also lead HER2+ cancer research groups to contact me and ultimately to greater involvement in cancer research.
Dr. Katia Cortese
University of Genoa
Read the Original
This page is a summary of: Trastuzumab Modulates the Protein Cargo of Extracellular Vesicles Released by ERBB2+ Breast Cancer Cells, Membranes, March 2021, MDPI AG,
DOI: 10.3390/membranes11030199.
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