What is it about?
Metabolism and DNA replication are the two most fundamental biological functions in life. Here we investigate how metabolism regulate replication.
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Why is it important?
DNA replication is responsible for faithfully copying genomes, propagating the genetic material from generation to generation. It must be tightly regulated to prevent the risk of replication errors and double-stranded DNA breaks, compromising genetic stability, cell viability and eventually causing diseases like cancer. Disruption of the metabolic control causes dramatic replication phenotypes. Understanding its mechanism is thus an important goal of fundamental et medical research.
Perspectives
I hope that this work and our previous publications on the same topic will inspire other researchers to study the mechanism and the role of metabolic control of replication from bacteria to humans.
Dr Laurent Janniere
Genopole, CNRS, UEVE, Paris-Saclay
Read the Original
This page is a summary of: The Replicative DnaE Polymerase of Bacillus subtilis Recruits the Glycolytic Pyruvate Kinase (PykA) When Bound to Primed DNA Templates, Life, April 2023, MDPI AG,
DOI: 10.3390/life13040965.
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