What is it about?
Disease-specific and commonly dysregulated miRNAs among AD, PD, and ALS have been found either in nervous tissues or in circulating fluids. In particular, altered expression of miR-124 and miR-218 was reported in all three NDs.
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Why is it important?
We have put in light a list of commonly dysregulated miRNAs in human post-mortem nervous tissues and circulating fluids of AD, PD, and ALS patients identifying 7 commonly dysregulated miRNAs. In particular, altered expression of miR-124 and miR-218 was reported in all three NDs, miR-133b and miR-338 were dysregulated in PD and ALS, miR-132 in both PD and AD, while miR-9 and miR-146a in AD and ALS.
Perspectives
Commonly dysregulated miRNAs in human post-mortem tissues and circulating fluids of AD, PD, and ALS patients could be used either as biomarkers or therapeutical targets using ASOs-based therapies, so targeting a single miRNA and affecting multiple pathogenic pathways.
Giulia Gentile
Consiglio Nazionale delle Ricerche
Read the Original
This page is a summary of: Dysregulated miRNAs as Biomarkers and Therapeutical Targets in Neurodegenerative Diseases, Journal of Personalized Medicine, May 2022, MDPI AG,
DOI: 10.3390/jpm12050770.
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