What is it about?
It is an overview on the role of the enteric nervous system in IBS appearance and evolution and as a possible target of drug therapies analyzing experimenatal models of he disease.
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Why is it important?
We studied the role played by the enteric nervous system in the genesis of IBS symptomatology and the available experimental or clinical pharmacological therapies affecting, directly or indirectly, the enteric neurotransmission.
Perspectives
The focus on targets related to specific symptoms has brought the production of drugs aimed to treat constipation or diarrhea with alternate results. This choice did not have attention on the possibility to look for drugs useful for global IBS symptoms. A more integrated view on the disease seems to be desirable for now, in order to develop efficient therapies that can counteract the chronic natural history of IBS.
Dr. Stefano Evangelista
Read the Original
This page is a summary of: Experimental Models of Irritable Bowel Syndrome and the Role of the Enteric Neurotransmission, Journal of Clinical Medicine, January 2018, MDPI AG,
DOI: 10.3390/jcm7010004.
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Contributors
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