What is it about?
This review highlights zebrafish as a valuable model to study innate immune responses in human infections. With genetic similarities to humans, zebrafish help uncover host-pathogen interactions for bacteria, viruses, and fungi, aiding in the discovery of new therapies.
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Why is it important?
Zebrafish offer a cost-effective, ethical model to study human immune responses, enabling insights into infection mechanisms and drug discovery that would be challenging or unethical in humans or mammals.
Perspectives
Future studies could expand zebrafish use to explore adaptive immunity, long-term host-pathogen interactions, and the role of new molecules like human serum albumin in infections, boosting therapeutic advances.
Professor Stefano Di Bella
Universita degli Studi di Trieste
Read the Original
This page is a summary of: Zebrafish (Danio rerio) as a Model System to Investigate the Role of the Innate Immune Response in Human Infectious Diseases, International Journal of Molecular Sciences, November 2024, MDPI AG,
DOI: 10.3390/ijms252212008.
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