What is it about?
This paper shows that cabotegravir (an antiretroviral drug used for HIV infection) is capable to inhibit melanoma cell growth and invasion in human melanoma cell lines in culture. The observed effect may be secondary to a downregulation of HERV genes.
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Why is it important?
It shed light on the potential of antiretrovirals in cancer research
Perspectives
Animal studies are needed
Professor Stefano Di Bella
Universita degli Studi di Trieste
Read the Original
This page is a summary of: Lamivudine, Doravirine, and Cabotegravir Downregulate the Expression of Human Endogenous Retroviruses (HERVs), Inhibit Cell Growth, and Reduce Invasive Capability in Melanoma Cell Lines, International Journal of Molecular Sciences, January 2024, MDPI AG,
DOI: 10.3390/ijms25031615.
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