Reveal the optimal core-shell nanocarrier system for the sorption of DOX, an anticancer drug

What is it about?

Doxorubicin (DOX) and other antibiotics from anthracycline series attract the atten-tion of the scientific community due to the simultaneous combination of positive and negative effects on human body. Furthermore, DOX plays a key role in the treatment of many neoplastic diseases, in particular cancer, even though its prolonged action causes cardiomyopathy and congestive heart failure. A strong desire to reduce cardio- and nephrotoxicity of DOX led to the idea of binding the drug to various nanomaterials, e.g., engineered nanoparticles.The aim of our study is to reveal the optimal core-shell nanocarrier system for the sorption of DOX, an anticancer drug.

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Why is it important?

In most studies the authors focus on developing magnetic nanocarrier with complex shell structure, however, such techniques are of little use in biomedical practice, since multi-stage synthesis is difficult and time-consuming. Furthermore, sorption and desorption processes on such modified particles sometimes last several days and have low efficiency. The aim of this work was to (i) obtain the IONs of 80–150 nm in size, (ii) modify their surface with cationic and anionic polyelectrolytes, nonionic polymer dextran, and porous carbon, and (iii) reveal the optimal core-shell system for the sorption of DOX, with the objective to develop and implement an effective nanocarrier for controlled drug delivery.

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