What is it about?

This study looks at how omega-3 fatty acids (commonly found in fish oil) might help with eye surface problems like dry eyes. It explores why these supplements seem to work well for some people but not for others, and suggests that our genes might play a role in this difference.

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Why is it important?

Understanding why omega-3 supplements work differently for different people is important because: Many eye surface problems involve long-lasting inflammation Omega-3 is often recommended to help reduce this inflammation If we know who it's likely to help, we can give better advice to patients It could lead to more personalized treatments for eye problems

Perspectives

Here's what the research shows: Many chronic eye surface problems involve inflammation Omega-3 fatty acids can help reduce inflammation in lab studies But in real-life trials, the results are mixed – it helps some people but not others This difference might be due to our genes, specifically ones related to how our body handles inflammation One particular gene, called LT-α, might predict how well someone will respond to omega-3 The researchers looked at how common different versions of this gene are in various ethnic groups They found that knowing someone's genetic makeup could help predict if omega-3 will work for them This research is like discovering that not all cars run on the same fuel. Just as some cars work better with different types of gas, our bodies might respond differently to omega-3 based on our genetic "engine". This could lead to more personalized treatments for eye problems. Instead of a one-size-fits-all approach, doctors might be able to test a person's genes and then recommend omega-3 supplements only to those who are likely to benefit. It's a step towards more effective, tailored treatments for eye surface problems.

Prof Louis Tong
National University of Singapore

Read the Original

This page is a summary of: Polymorphisms in Lymphotoxin-Alpha as the “Missing Link” in Prognosticating Favourable Response to Omega-3 Supplementation for Dry Eye Disease: A Narrative Review, International Journal of Molecular Sciences, February 2023, MDPI AG,
DOI: 10.3390/ijms24044236.
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