What is it about?

This review looks at studies that have tested using omega-3 fatty acids (commonly found in fish oil) as eye drops to treat dry eyes. It compares results from both human and animal studies to see if this could be a promising new treatment.

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Why is it important?

Exploring new treatments for dry eyes is important because: Dry eye is a common and uncomfortable problem for many people Oral omega-3 supplements haven't been as helpful as hoped in recent big studies Eye drops might deliver the benefits of omega-3 directly where they're needed

Perspectives

Here's what the review found: They looked at 10 studies in total - 5 on humans and 5 on animals In humans, omega-3 eye drops seemed to help in several ways: The surface of the eye looked healthier Tears stayed on the eye longer before drying up There were mixed results on whether it helped with symptoms or with oil glands in the eyelids It didn't seem to make people produce more tears Animal studies backed up these findings and also showed: Less inflammation in the eye Fewer inflammatory cells in the eye However, there aren't many studies on this yet, especially in humans More research is needed to figure out how well it works and what the best dose might be This research is like discovering a new recipe that might help soothe dry eyes. Instead of taking fish oil capsules, putting it directly in the eye as drops could be more effective. While the early results look promising, scientists are saying we need more taste-testers (in this case, human studies) before we can say for sure how well it works. It's an exciting new direction that could lead to better treatments for people struggling with dry eyes, but we need more evidence before it becomes a common treatment.

Prof Louis Tong
National University of Singapore

Read the Original

This page is a summary of: Topical Omega-3 Fatty Acids Eyedrops in the Treatment of Dry Eye and Ocular Surface Disease: A Systematic Review, International Journal of Molecular Sciences, October 2022, MDPI AG,
DOI: 10.3390/ijms232113156.
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