Acellular Dermal Matrix Used in Diabetic Foot Ulcers

What is it about?

Herein, the surgical approach focused on the targeted use of the acellular dermal matrix has been integrated with biochemical and morphological/histological analyses to obtain evidence-based information on the mechanisms underlying tissue regeneration. In this research report, the clinical results indicated decreased postoperative wound infection levels and a short healing time, with a sound regeneration of tissues.

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Photo by Compare Fibre on Unsplash

Photo by Compare Fibre on Unsplash

Why is it important?

Clinical evaluation of improved healing of DFUs was, for the first time, supported by biochemical and histological analyses during the regeneration time frame. Biopsy withdrawn at specific time intervals after surgery may help in assessing the healing stage and the quality of the new tissue. IDRT and IFWM provide effective tissue regeneration at molecular, histological and clinical levels, with a decrease in the inflammatory response. The results obtained represent a good starting point for exploring the acellular dermal matrix potentialities in tissue regeneration. Even if other studies are necessary to elucidate some aspects of the beneficial effect of these biomaterials in DFUs, the present data shed light on key biomarkers for molecular monitoring of the healing progress. Timely repair is a critical point to reduce infection, hospitalization and amputation; all the latter may have a major impact on health care systems and thus affect social aspects, especially considering the aging of population in western countries.