What is it about?
The more we learned about cancer, the more complex it appeared to be. This medical problem posed a huge and complex challenge because cancer elude most of the classical therapies; it develop using at least two distinct chains, which until now have not been addressed simultaneously from a therapeutic point of view, such as inhibiting the aberrant telomerase activity, by which cancer cells could live indefinitely, and also inhibiting the release of HIF-1 hypoxia growth factors in order to stimulate extracellular ATP production followed by immediate internalisation, therefore the cancer cell can use this huge amount of energy to multiply indefinitely. There are also other factors but these two chains of cancer evolution are highly important. The latest two known novel and most promising therapies which could be addressed in a targeted way are the immune checkpoint therapy and the metabolic mitochondrial reprogramming, which if they could be addressed in a conjunction protocol, then the cancer cells may not be needed to be killed, but only corrected in order to start behaving as much as like normal cells and inhibit their growth, correcting their DNA damages and / or mutations, if possible, and also reprogramming the internal mitochondria, to start producing the own ATP, thus inhibiting the release of hypoxia growth factor for external ATP production. But this is still not enough, because many other factors could continue to contribute cancer promotion, such as a wrong diet, lifestyle and stress, therefore, before and after the clinical therapies, dietary and/or fasting plans must be addressed, along with psyhotherapies. Special personalized dietary plans are also needed during clinical therapies.
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Why is it important?
Although even this new complex proposal might not cure cancer, this is important because the patient might gain long enough time in order to change his lifestyle, reduce stress, apply dietary personalized protocols and enhanced his immune system in order to be be able to mark and fagocitize the cancer cells until the last cell have been consumed and the body will be long term free of any cancer cell. So the second part of this scientific application is in the patient responsibility.
Perspectives
The same model used for understanding of cancer, may be addressed in future papers in order to explain Alzheimer's, Parkinson, MS and Muscular Dystrophy, by gathering many pieces of information, which already may be available on the medical databases, but there are only few review papers.
Biological Transformations Controlled by the Mind - MURESANU CRISTIAN
Research Center for Applied Biotechnology in Diagnosis and Molecular Therapies (BIODIATECH)
Read the Original
This page is a summary of: Updated Understanding of Cancer as a Metabolic and Telomere-Driven Disease, and Proposal for Complex Personalized Treatment, a Hypothesis, International Journal of Molecular Sciences, September 2020, MDPI AG,
DOI: 10.3390/ijms21186521.
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Updated Understanding of Cancer as a Metabolic and Telomere-Driven Disease, and Proposal for Complex Personalized Treatment, a Hypothesis
In this review, we propose a holistic approach to understanding cancer as a metabolic disease. We have proposed complex personalized treatments that seek to correct multiple changes simultaneously using a psychological approach to reduce chronic stress, immune checkpoint therapy with reduced doses of chemo and radiotherapy, minimal surgical intervention, if any, and mitochondrial metabolic reprogramming protocols supplemented by intermittent fasting and personalized dietary plans without interfering with the other therapies.
Updated Understanding of Cancer
There is no miracle cure for cancer, and if the patient is not participating with great interest and sincerity at these therapies, then the results might not be good enough. But will all these offering logic tohim much longer time than any of them applied only as single ? We believe so, yes, and it would be make this assumption, because it could be in the benefit of the patient, because even if the progression of cancer stopped at a certain stage but does not progress more than that, the patient may survive many years, maybe without relapse, if he sticked to the dietary guidelines, psychotherapy sessions and lower the emotional stress. But that means the patients need to be educated in this regard.
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