What is it about?
This review is to highlight the impacts of diet, gut microbiota, and epigenetic crosstalk on altered gene expression in NDM.
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Why is it important?
The exact mechanisms by which diet in GDM alters gut microbiota composition, which may in turn influence gene expression in NDM, are not well understood. A potential hypothesis is that epigenetic mechanisms mediate the effects of diet-microbiota interactions on altering gene expression in NDM. In general, there is a complex interaction between epigenetics, diet, and gut microbiota that can influence gene expression profiles in NDM.
Perspectives
Further studies are needed to explore the mechanisms for the pro- and anti-inflammatory effects of commensal and pathogenic bacteria on susceptibility to NDM-related genes in response to maternal diet in GDM.
Dr Naser Alsharairi
Griffith University
Read the Original
This page is a summary of: Exploring the Diet-Gut Microbiota-Epigenetics Crosstalk Relevant to Neonatal Diabetes, Genes, April 2023, MDPI AG,
DOI: 10.3390/genes14051017.
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Contributors
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