What is it about?
We compared the miRNA (small regulatory RNA) secreted in extracellular vesicles with miRNA predominently cellular using next generation sequencing. With bioinformatics analysis we identified their potential effect on cells, we observed that only the miRNA secreted in Extracellular vesicles were likely to control the activity and health of the central nervous system. This explains the effect of extracellular vesicles observed on neurons in other published research.
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Why is it important?
We used astrocytes from adult human donors instead of from new born rodents. We provide an inventory of small RNA in astrocytes and astrocyte secreted vesicles and show that there is a large amount of uncharacterized RNA in secreted vesicles, which could be developed as biomarker.
Perspectives
We propose am inventory of small RNA secreted by the main glial cells in the central nervous system. As more data will be generated from this type of cells from adult donor in the future, a better understanding of interaction in the human brain will be possible.
Dr Geneviève Bart
university of Oulu
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This page is a summary of: Human Adult Astrocyte Extracellular Vesicle Transcriptomics Study Identifies Specific RNAs Which Are Preferentially Secreted as EV Luminal Cargo, Genes, March 2023, MDPI AG,
DOI: 10.3390/genes14040853.
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