What is it about?
The aim of this case-control study was to evaluate the correlation between polymorphisms at the level of exon 1 from the CTLA-4 gene and the susceptibility to developing HT.
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Why is it important?
Therefore, in the present study, we aimed to determine whether there is a role played by CTLA-4 genotypes at rs231775 and other new SNPs in exon 1, which we determined using Sanger sequencing among seropositive patients to evaluate their role between CTLA-4 genotypes and susceptibility and influence in the increase of anti-TPO and anti-TG antibody titers in AITDs. We demonstrate for the first time that C55A polymorphism is positively associated with disease, specifically HT.
Perspectives
the results of our study demonstrated, for the first time, a genetic relationship between the CTLA-4 (+55A/GG) genotype and the seropositivity of the thyroid autoantigens TPO and TG. To date, there is no other evidence available regarding this point mutation and its phenotypic effect in Romanian patients with AITDs and other parts of the world
PhD, MD racataianu nicoleta
UMF Iuliu Hatieganu Cluj-Napoca Romania
Read the Original
This page is a summary of: The C55A Single Nucleotide Polymorphism in CTLA-4 Gene, a New Possible Biomarker in Thyroid Autoimmune Pathology Such as Hashimoto’s Thyroiditis, Diagnostics, July 2023, MDPI AG,
DOI: 10.3390/diagnostics13152517.
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