A complex relationship between extracellular matrix, insulin resistance, and skeletal muscle

What is it about?

The skeletal muscle is the core tissue of insulin-mediated glucose uptake within the body. The extracellular matrix (ECM) provides integrity and biochemical signals and plays a crucial role in myogenesis; it also undergoes remodeling upon injury, which is related to insulin resistance (IR). Here, we reviewed the relationship between the ECM, IR, and skeletal muscle and discussed briefly the clinical and non-clinical aspect of ECM remodelling and IR

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Why is it important?

An in-depth study of the connection between ECM remodeling of the skeletal muscle, the action mechanism of insulin, and integrin signaling will be a promising innovative line of research to develop novel therapeutics.