What is it about?
miRNA is usually regarded to bind to seed region of target mRNA and interrupt translation. However, off-targe effect is often observed. This is the first report about comprehensive miRNA sequence non-specific off target effect.
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Why is it important?
mRNA affected by miRNA sequence non-specific off target effect is universal, i.e., independent of transfected miRNAs or cell lines. Thus it is expected to play various critical roles.
Perspectives
As a bioinformatic researcher, it is a part of paper about the applications of tensor decomposition based unsupervised feature extraction applied to bioinformatics problem.
Professor Y-h. Taguchi
Chuo Daigaku
Read the Original
This page is a summary of: Tensor Decomposition-Based Unsupervised Feature Extraction Can Identify the Universal Nature of Sequence-Nonspecific Off-Target Regulation of mRNA Mediated by MicroRNA Transfection, Cells, June 2018, MDPI AG,
DOI: 10.3390/cells7060054.
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