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Cytochrome P450-overexpressing HepG2 cells are a very good complement for the evaluation of the metabolic stability of radiotracers and additionally allow the analysis of the CYP isoform-specific contribution to the overall radiotracer metabolism.
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This page is a summary of: Investigation of Radiotracer Metabolic Stability In Vitro with CYP-Overexpressing Hepatoma Cell Lines, Cells, August 2022, MDPI AG,
DOI: 10.3390/cells11152447.
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