Inflamed gums increase the risk of diabetes mellitus by increase the glycation products

What is it about?

Diabetes mellitus is one most of non-communicable diseases affecting mankind today. It's is estimated that more half of global population of the population will affected by Diabetes. Many risk factors increase the risk of diabetes mellitus. Among all the risk factors that affect Diabetes mellitus, gums disease are considered as one of most common risk factors for Diabetes Mellitus. Gum diseases, scientifically referred to as gingivitis and periodontitis increasing the risk of diabetes mellitus by affecting pancreatic functions, insulin resistance, and increasing the inflammation in the body. One of the key way by periodontitis increase the risk of Diabetes by increasing the formation of glycation end products. Studies have found that patients with periodontitis have higher advanced glycation end products compared to those with good oral health. Advanced glycation end products are produced when excess glucose is broken down and metabolized into glycation product such carboxy methyl lysine and carboxy ethyl lysine. This systematic review assess and evaluate studies that evaluate the role of periodontits on glycation levels

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Why is it important?

The role of oral health and its relation to general health is one of major and growing global health area of research. Periodontal disease and diabetes mellitus are two of the most prevalent diseases affecting mankind today. There is a two way connection between diabetes and gum disease. It is well known that patients with uncontrolled diabetes melltus has more bone loss around teeth, tooth mobility, and tooth loss. People with Diabetes have higher risk of gum diseases. On other hand inflamed gums also increase the risk of DM. Hence it is important to understand how periodontal diseases can increase blood glucose levels

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